3U54
Crystal structure (Type-1) of SAICAR synthetase from Pyrococcus horikoshii OT3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004639 | molecular_function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0009236 | biological_process | cobalamin biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004639 | molecular_function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0009236 | biological_process | cobalamin biosynthetic process |
| B | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BU1 A 410 |
| Chain | Residue |
| A | GLU111 |
| A | LEU112 |
| A | PRO113 |
| B | HIS63 |
| B | LYS155 |
| B | CD401 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 420 |
| Chain | Residue |
| A | ARG198 |
| A | ARG93 |
| A | GLY98 |
| A | SER99 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD A 400 |
| Chain | Residue |
| A | GLU158 |
| A | ASP162 |
| B | GLU158 |
| B | ASP162 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CD A 401 |
| Chain | Residue |
| A | HIS63 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD A 402 |
| Chain | Residue |
| A | GLU89 |
| A | ASP128 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD A 403 |
| Chain | Residue |
| A | ASP35 |
| A | HIS127 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD A 404 |
| Chain | Residue |
| A | GLU81 |
| A | ASP181 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 421 |
| Chain | Residue |
| A | THR32 |
| A | ALA33 |
| A | LYS210 |
| A | HOH375 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CD B 401 |
| Chain | Residue |
| A | GLU111 |
| A | BU1410 |
| B | HIS63 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD B 402 |
| Chain | Residue |
| B | GLU89 |
| B | ASP128 |
| B | HOH302 |
| B | HOH351 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CD B 403 |
| Chain | Residue |
| B | ASP35 |
| B | HIS127 |
| B | HOH301 |
| B | HOH303 |
| B | HOH373 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD B 404 |
| Chain | Residue |
| B | GLU81 |
| B | ASP181 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD B 405 |
| Chain | Residue |
| A | ASP19 |
| A | ASP21 |
| A | LYS22 |
| B | GLU125 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CD B 406 |
| Chain | Residue |
| B | GLU226 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 420 |
| Chain | Residue |
| B | ARG93 |
| B | GLY98 |
| B | SER99 |
| B | ARG198 |
| B | HOH380 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 421 |
| Chain | Residue |
| B | THR32 |
| B | ALA33 |
| B | PHE34 |
| B | LYS210 |
| B | ARG214 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 430 |
| Chain | Residue |
| B | MET15 |
| B | HIS68 |
| B | MSE85 |
| B | ASP190 |
Functional Information from PROSITE/UniProt
