3U3K

Crystal structure of hSULT1A1 bound to PAP and 2-Naphtol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004062	molecular_function	aryl sulfotransferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006068	biological_process	ethanol catabolic process
A	0006584	biological_process	catecholamine metabolic process
A	0006629	biological_process	lipid metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0008146	molecular_function	sulfotransferase activity
A	0008202	biological_process	steroid metabolic process
A	0008210	biological_process	estrogen metabolic process
A	0009308	biological_process	amine metabolic process
A	0009812	biological_process	flavonoid metabolic process
A	0016740	molecular_function	transferase activity
A	0042403	biological_process	thyroid hormone metabolic process
A	0042420	biological_process	dopamine catabolic process
A	0047894	molecular_function	flavonol 3-sulfotransferase activity
A	0050294	molecular_function	steroid sulfotransferase activity
A	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
A	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
A	0051923	biological_process	sulfation
B	0004062	molecular_function	aryl sulfotransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006068	biological_process	ethanol catabolic process
B	0006584	biological_process	catecholamine metabolic process
B	0006629	biological_process	lipid metabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0008146	molecular_function	sulfotransferase activity
B	0008202	biological_process	steroid metabolic process
B	0008210	biological_process	estrogen metabolic process
B	0009308	biological_process	amine metabolic process
B	0009812	biological_process	flavonoid metabolic process
B	0016740	molecular_function	transferase activity
B	0042403	biological_process	thyroid hormone metabolic process
B	0042420	biological_process	dopamine catabolic process
B	0047894	molecular_function	flavonol 3-sulfotransferase activity
B	0050294	molecular_function	steroid sulfotransferase activity
B	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
B	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
B	0051923	biological_process	sulfation

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE A3P A 2001

Chain	Residue
A	LYS48
A	THR227
A	SER228
A	PHE229
A	MET232
A	PHE255
A	MET256
A	ARG257
A	LYS258
A	GLY259
A	HOH315
A	SER49
A	HOH316
A	HOH344
A	GLY50
A	THR51
A	THR52
A	TRP53
A	ARG130
A	SER138
A	TYR193

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 03V A 2002

Chain	Residue
A	ILE21
A	PHE81
A	LYS106
A	HIS108
A	PHE142
A	VAL148
A	HIS149
A	MET248
A	HOH316

---

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE A3P B 2001

Chain	Residue
B	LYS48
B	SER49
B	GLY50
B	THR51
B	THR52
B	TRP53
B	ARG130
B	SER138
B	TYR193
B	THR227
B	SER228
B	PHE229
B	MET232
B	PHE255
B	MET256
B	ARG257
B	LYS258
B	GLY259
B	HOH324
B	HOH326
B	HOH337
B	HOH338

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 03V B 2002

Chain	Residue
B	LYS106
B	HIS108
B	PHE142
B	HIS149
B	PHE247
B	MET248
B	HOH337

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P0DMM9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	38
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12471039","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16221673","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P17988","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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