3U1P

Crystal Structure of M. tuberculosis LD-transpeptidase type 2 with Modified Catalytic Cysteine (C354)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016740	molecular_function	transferase activity
B	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG A 501

Chain	Residue
A	ASP323
A	HOH626

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG B 501

Chain	Residue
B	ASN242
B	GLN244
B	SER306
B	HOH647
B	HOH665

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000305|PubMed:23103390

Chain	Residue	Details
A	HIS336
B	HIS336

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000269|PubMed:23103390

Chain	Residue	Details
A	CSO354
B	CSO354

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP232
A	GLU235
A	GLY236
B	ASP232
B	GLU235
B	GLY236

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
A	TYR318
A	SER331
A	ASN356
B	TYR318
B	SER331
B	ASN356

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: Binds to carbapenem drug (covalent) => ECO:0000250

Chain	Residue	Details
A	CSO354
B	CSO354

---