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3TYV

SAR development and discovery of potent indole-based inhibitors of the hepatitis C virus NS5B polymerase

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-directed RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-directed RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE PO4 A 577
ChainResidue
APRO265
AHOH1146
ATYR276
AARG505
AVAL530
AARG531
ATHR532
AHOH702
AHOH850
AHOH1121

site_idAC2
Number of Residues21
DetailsBINDING SITE FOR RESIDUE HI3 A 578
ChainResidue
APHE193
AARG200
AASN316
ACYS366
ASER367
ALEU384
AGLY410
AASN411
AMET414
ATYR415
AGLN446
AILE447
ATYR448
AGLY449
ASER556
AHOH598
AHOH669
AHOH772
AHOH784
AHOH874
AHOH1090

site_idAC3
Number of Residues21
DetailsBINDING SITE FOR RESIDUE HI3 B 577
ChainResidue
BPHE193
BARG200
BASN316
BCYS366
BSER367
BLEU384
BGLY410
BASN411
BMET414
BTYR415
BGLN446
BILE447
BTYR448
BGLY449
BSER556
BHOH582
BHOH623
BHOH651
BHOH655
BHOH749
BHOH750

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues236
DetailsDomain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P26663","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"UniProtKB","id":"P26662","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

245663

PDB entries from 2025-12-03

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