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3TYQ

SAR development and discovery of potent indole-based inhibitors of the hepatitis c virus NS5B polymerase

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-directed RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-directed RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE HI4 A 577
ChainResidue
APHE193
AGLN446
AILE447
ATYR448
AHOH718
AHOH795
AHOH912
AHOH945
AHOH1157
AHOH1473
AHOH5004
AASN316
AASP318
AASP319
ACYS366
AGLY410
AASN411
AMET414
ATYR415

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE PO4 A 578
ChainResidue
AARG505
AVAL530
AARG531
ATHR532
AHOH601
AHOH785
AHOH863
AHOH876
AHOH1081
AHOH1212
AHOH1606

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PO4 A 579
ChainResidue
AARG114
AHOH636
AHOH760
AHOH1404
BGLY516
BARG517

site_idAC4
Number of Residues18
DetailsBINDING SITE FOR RESIDUE HI4 B 577
ChainResidue
BPHE193
BASN316
BASP318
BASP319
BCYS366
BASN411
BMET414
BTYR415
BGLN446
BILE447
BTYR448
BHOH672
BHOH688
BHOH736
BHOH819
BHOH821
BHOH880
BHOH5001

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PO4 B 578
ChainResidue
APRO22
AARG401
AHOH991
BARG114
BHOH712
BHOH805
BHOH1475

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues236
DetailsDomain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P26663","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"UniProtKB","id":"P26662","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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