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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3TXH

HEWL co-crystallization with carboplatin in DMSO media with glycerol as the cryoprotectant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0016231	molecular_function	beta-N-acetylglucosaminidase activity
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1130

Chain	Residue
A	TYR23
A	ASN113

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1131

Chain	Residue
A	SER24
A	GLY26
A	GLN121
A	DMS139

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1132

Chain	Residue
A	SER72
A	GLY67
A	ARG68
A	THR69

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1134

Chain	Residue
A	PHE38
A	GOL136

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1135

Chain	Residue
A	ASN65
A	PRO79
A	GOL137

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1136

Chain	Residue
A	ARG73
A	ASN74

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 1137

Chain	Residue
A	ALA42
A	ASN44
A	ARG68
A	GOL151
A	HOH2042
A	HOH2044

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 1138

Chain	Residue
A	SER60
A	CYS64
A	SER72
A	ARG73
A	HOH2077
A	HOH2082

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE QPT A 130

Chain	Residue
A	HIS15
A	DMS141
A	HOH2105

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE QPT A 131

Chain	Residue
A	ARG14
A	HIS15
A	ILE88
A	DMS143
A	HOH2010

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 132

Chain	Residue
A	GLN57
A	ILE58
A	ASN59
A	TRP63
A	ALA107
A	HOH2069
A	HOH2112

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 133

Chain	Residue
A	ARG5
A	ALA122
A	TRP123
A	GOL149
A	HOH2048

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 134

Chain	Residue
A	HIS15
A	LYS96
A	DMS141
A	HOH2106

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 135

Chain	Residue
A	ASN93
A	LYS97
A	HOH2087

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 801

Chain	Residue
A	LEU75
A	ASP101
A	GOL136

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 136

Chain	Residue
A	LYS33
A	ASN37
A	TRP62
A	GOL801
A	CL1134
A	HOH2045
A	HOH2046

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 137

Chain	Residue
A	PRO79
A	SER86
A	CL1135

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 138

Chain	Residue
A	ARG61
A	TRP62
A	GLY71
A	SER72
A	ARG73
A	HOH2080

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 139

Chain	Residue
A	SER24
A	DMS140
A	CL1131
A	HOH2116

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 140

Chain	Residue
A	LYS33
A	PHE34
A	THR118
A	TRP123
A	DMS139
A	GOL149
A	HOH2131

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 141

Chain	Residue
A	ARG14
A	GLY16
A	ARG128
A	QPT130
A	DMS134

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 142

Chain	Residue
A	ASN103
A	ALA107
A	ARG125
A	GOL148

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 143

Chain	Residue
A	HOH2009
A	ALA11
A	ARG14
A	HIS15
A	QPT131

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 144

Chain	Residue
A	ASP101
A	GLY102
A	ARG125
A	GOL147
A	HOH2133

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 145

Chain	Residue
A	ASN44
A	ARG45
A	ASN46
A	ASP52
A	HOH2068

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 146

Chain	Residue
A	ARG45
A	GLY49
A	ARG68
A	PRO70
A	GOL151

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 147

Chain	Residue
A	GLY102
A	ASN103
A	ASP119
A	GOL144
A	GOL149

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 148

Chain	Residue
A	ASN106
A	ARG112
A	DMS142

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 149

Chain	Residue
A	GLY117
A	ASP119
A	DMS133
A	DMS140
A	GOL147
A	HOH2125

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 150

Chain	Residue
A	TRP63
A	LEU75
A	LYS97
A	HOH2108

site_id	DC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 151

Chain	Residue
A	ASP18
A	ASN19
A	ARG45
A	ARG128
A	GOL146
A	CL1137
A	HOH2024

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC

Chain	Residue	Details
A	CYS76-CYS94

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	128
Details	Domain: {"description":"C-type lysozyme","evidences":[{"source":"PROSITE-ProRule","id":"PRU00680","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
A	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	ASN46
A	ASP48
A	SER50
A	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
A	ASN59

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PDB entries from 2025-10-01

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