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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3TXG

HEWL co-crystallization with cisplatin in DMSO media with paratone as the cryoprotectant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0016231	molecular_function	beta-N-acetylglucosaminidase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1130

Chain	Residue
A	TYR23
A	ASN113

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1131

Chain	Residue
A	SER24
A	GLY26
A	GLN121

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 1132

Chain	Residue
A	SER72
A	ASN65
A	GLY67
A	ARG68
A	THR69

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1134

Chain	Residue
A	LYS33
A	DMS133

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1135

Chain	Residue
A	ASN65
A	DMS147
A	HOH2085

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1136

Chain	Residue
A	ARG73
A	ASN74

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 1137

Chain	Residue
A	ALA42
A	ASN44
A	ARG68
A	DMS145
A	HOH2044

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 1138

Chain	Residue
A	SER60
A	CYS64
A	SER72
A	ARG73
A	HOH2077
A	HOH2082

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CPT A 130

Chain	Residue
A	ARG14
A	HIS15
A	ASP87
A	ILE88
A	THR89

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CPT A 131

Chain	Residue
A	ARG14
A	HIS15
A	ASN93
A	DMS140

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 132

Chain	Residue
A	GLN57
A	ILE58
A	ASN59
A	TRP63
A	ILE98
A	ALA107
A	TRP108

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 133

Chain	Residue
A	LYS33
A	TRP62
A	ARG73
A	CL1134
A	HOH2004
A	HOH2045
A	HOH2046

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 134

Chain	Residue
A	ARG5
A	ALA122
A	TRP123

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 135

Chain	Residue
A	LEU75
A	LYS97
A	DMS136

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 136

Chain	Residue
A	ASP101
A	DMS135
A	HOH2108

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 137

Chain	Residue
A	ASN93
A	LYS97
A	HOH2087
A	HOH2103
A	HOH2104

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 138

Chain	Residue
A	TRP62
A	ASP101
A	DMS139

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 139

Chain	Residue
A	ILE98
A	ASP101
A	ASN103
A	ALA107
A	DMS138
A	HOH2110

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 140

Chain	Residue
A	LYS96
A	CPT131
A	DMS143

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 141

Chain	Residue
A	ASN37
A	ASN39
A	GLY67
A	ARG68
A	HOH2044

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 142

Chain	Residue
A	ASP48
A	SER50
A	ARG61
A	THR69
A	PRO70

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 143

Chain	Residue
A	ARG14
A	GLY16
A	THR47
A	ARG128
A	DMS140

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 144

Chain	Residue
A	ASN44
A	ARG45
A	HOH2024
A	HOH2027
A	HOH2055

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 145

Chain	Residue
A	ARG45
A	THR51
A	ARG68
A	CL1137
A	HOH2065
A	THR43
A	ASN44

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 146

Chain	Residue
A	GLU35
A	ASN44
A	ASP52
A	GLN57
A	HOH2038

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 147

Chain	Residue
A	LYS1
A	GLN41
A	CL1135
A	HOH2001
A	HOH2002
A	HOH2003

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC

Chain	Residue	Details
A	CYS76-CYS94

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
A	GLU35
A	ASP52

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	ASP101

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
A	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	ASN46
A	ASP48
A	SER50
A	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
A	ASN59

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PDB entries from 2024-10-16

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