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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3TXF

HEWL co-crystallization with cisplatin in DMSO media with glycerol as the cryoprotectant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0008152	biological_process	metabolic process
A	0016231	molecular_function	beta-N-acetylglucosaminidase activity
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1130

Chain	Residue
A	TYR23
A	ASN113
A	DMS133

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 1131

Chain	Residue
A	SER24
A	GLY26
A	GLN121
A	GOL146
A	GOL156

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CL A 1132

Chain	Residue
A	ARG68
A	THR69
A	SER72
A	DMS148
A	DMS153
A	HOH2029
A	GLY67

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1134

Chain	Residue
A	PHE38
A	DMS135
A	GOL159

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1135

Chain	Residue
A	ASN65
A	PRO79
A	GOL165

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1136

Chain	Residue
A	ARG73
A	ASN74

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1137

Chain	Residue
A	ALA42
A	ARG68
A	GOL142
A	HOH2044

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 1138

Chain	Residue
A	SER60
A	CYS64
A	SER72
A	ARG73
A	DMS148

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CPT A 130

Chain	Residue
A	HIS15
A	GOL143

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMS A 131

Chain	Residue
A	ARG5
A	TRP123
A	GOL139
A	GOL147
A	DMS149
A	GOL159
A	GOL162
A	HOH2048

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 132

Chain	Residue
A	ALA10
A	ALA10
A	LYS13
A	ARG14
A	ARG128
A	LEU129

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 133

Chain	Residue
A	ARG21
A	GLU35
A	GOL141
A	CL1130
A	HOH2038
A	HOH2041
A	HOH2043

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 134

Chain	Residue
A	ARG45
A	ASN46
A	ARG128
A	DMS136
A	GOL143

site_id	BC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE DMS A 135

Chain	Residue
A	LYS33
A	ASN37
A	TRP62
A	ARG73
A	DMS155
A	GOL156
A	GOL157
A	GOL159
A	GOL163
A	CL1134
A	HOH2045
A	HOH2046

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 136

Chain	Residue
A	GLY16
A	LYS96
A	DMS134
A	GOL143

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 137

Chain	Residue
A	PRO79
A	SER86
A	DMS151
A	GOL165

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMS A 138

Chain	Residue
A	GLN57
A	ILE58
A	ASN59
A	TRP63
A	ILE98
A	ALA107
A	HOH2069
A	HOH2112

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 801

Chain	Residue
A	ARG61
A	TRP62
A	GLY71
A	GOL146
A	GOL156
A	HOH2046
A	HOH2072
A	HOH2083

site_id	CC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 139

Chain	Residue
A	GLY102
A	DMS131
A	GOL141
A	GOL145
A	GOL147
A	DMS152
A	GOL166
A	HOH2133
A	ARG5
A	SER100
A	ASP101

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 140

Chain	Residue
A	TRP63
A	LEU75
A	ASP101
A	DMS155
A	GOL159
A	GOL160
A	GOL163

site_id	CC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 141

Chain	Residue
A	ARG21
A	VAL99
A	GLY102
A	VAL109
A	DMS133
A	GOL139
A	GOL145
A	HOH2109

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 142

Chain	Residue
A	ASN19
A	ARG45
A	ARG68
A	DMS150
A	GOL164
A	CL1137
A	HOH2024

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 143

Chain	Residue
A	ARG14
A	GLY16
A	ARG128
A	CPT130
A	DMS134
A	DMS136

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 144

Chain	Residue
A	LYS13
A	PRO70
A	PRO70
A	LEU129
A	GOL158

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 145

Chain	Residue
A	ARG21
A	ARG125
A	GLY126
A	GOL139
A	GOL141
A	DMS152

site_id	CC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 146

Chain	Residue
A	GLN121
A	ILE124
A	DMS150
A	GOL156
A	GOL164
A	GOL801
A	CL1131

site_id	CC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 147

Chain	Residue
A	ASP101
A	ASN103
A	ASP119
A	DMS131
A	GOL139
A	GOL159
A	GOL162
A	GOL166

site_id	DC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DMS A 148

Chain	Residue
A	SER60
A	CYS64
A	ASN65
A	ASP66
A	GLY67
A	ARG68
A	THR69
A	SER72
A	CL1132
A	NA1138

site_id	DC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE DMS A 149

Chain	Residue
A	PHE34
A	THR118
A	DMS131
A	GOL157
A	GOL159
A	GOL162
A	HOH2125
A	HOH2128
A	HOH2131

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 150

Chain	Residue
A	ASN37
A	ARG68
A	GOL142
A	GOL146
A	GOL164
A	HOH2078

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 151

Chain	Residue
A	ILE78
A	PRO79
A	DMS137
A	HOH2034
A	HOH2088

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 152

Chain	Residue
A	ARG5
A	SER100
A	GOL139
A	GOL145
A	GOL160

site_id	DC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 153

Chain	Residue
A	SER72
A	CL1132
A	HOH2029
A	HOH2075
A	HOH2079
A	HOH2081

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 154

Chain	Residue
A	ASN103
A	ASN106
A	ALA107

site_id	DC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 155

Chain	Residue
A	GLY4
A	ARG5
A	LEU75
A	DMS135
A	GOL140
A	GOL160

site_id	DC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GOL A 156

Chain	Residue
A	SER24
A	ASN37
A	VAL120
A	GLN121
A	DMS135
A	GOL146
A	GOL157
A	GOL163
A	GOL164
A	GOL801
A	CL1131
A	HOH2046

site_id	EC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GOL A 157

Chain	Residue
A	SER24
A	LYS33
A	PHE34
A	ASN37
A	DMS135
A	DMS149
A	GOL156
A	GOL159
A	GOL164
A	HOH2031
A	HOH2036
A	HOH2116

site_id	EC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 158

Chain	Residue
A	ASP48
A	ARG61
A	THR69
A	PRO70
A	SER72
A	GOL144

site_id	EC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 159

Chain	Residue
A	TRP123
A	DMS131
A	DMS135
A	GOL140
A	GOL147
A	DMS149
A	GOL157
A	GOL163
A	CL1134

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 160

Chain	Residue
A	LEU75
A	LYS97
A	GOL140
A	DMS152
A	DMS155
A	HOH2008

site_id	EC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 161

Chain	Residue
A	TYR20
A	LYS96
A	LYS97
A	SER100
A	HOH2103

site_id	EC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 162

Chain	Residue
A	GLY117
A	THR118
A	ASP119
A	DMS131
A	GOL147
A	DMS149
A	GOL166
A	HOH2124

site_id	EC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 163

Chain	Residue
A	TRP62
A	ASP119
A	GLN121
A	ARG125
A	DMS135
A	GOL140
A	GOL156
A	GOL159

site_id	EC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 164

Chain	Residue
A	ASN19
A	GLY22
A	SER24
A	ASN37
A	GOL142
A	GOL146
A	DMS150
A	GOL156
A	GOL157
A	HOH2036
A	HOH2116

site_id	EC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 165

Chain	Residue
A	LYS1
A	DMS137
A	CL1135
A	HOH2003
A	HOH2076

site_id	FC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 166

Chain	Residue
A	GLY102
A	ASN103
A	ARG112
A	GOL139
A	GOL147
A	GOL162

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC

Chain	Residue	Details
A	CYS76-CYS94

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
A	GLU35
A	ASP52

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	ASP101

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
A	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	ASN46
A	ASP48
A	SER50
A	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
A	ASN59

218500

PDB entries from 2024-04-17

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