3TWS
Crystal structure of ARC4 from human Tankyrase 2 in complex with peptide from human TERF1 (chimeric peptide)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003950 | molecular_function | NAD+ ADP-ribosyltransferase activity |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0032212 | biological_process | positive regulation of telomere maintenance via telomerase |
| A | 0051225 | biological_process | spindle assembly |
| B | 0003950 | molecular_function | NAD+ ADP-ribosyltransferase activity |
| B | 0016055 | biological_process | Wnt signaling pathway |
| B | 0032212 | biological_process | positive regulation of telomere maintenance via telomerase |
| B | 0051225 | biological_process | spindle assembly |
| C | 0003950 | molecular_function | NAD+ ADP-ribosyltransferase activity |
| C | 0016055 | biological_process | Wnt signaling pathway |
| C | 0032212 | biological_process | positive regulation of telomere maintenance via telomerase |
| C | 0051225 | biological_process | spindle assembly |
| D | 0003950 | molecular_function | NAD+ ADP-ribosyltransferase activity |
| D | 0016055 | biological_process | Wnt signaling pathway |
| D | 0032212 | biological_process | positive regulation of telomere maintenance via telomerase |
| D | 0051225 | biological_process | spindle assembly |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PE8 A 1 |
| Chain | Residue |
| A | HOH50 |
| D | HOH43 |
| D | TYR572 |
| D | GLU576 |
| D | GLN613 |
| D | HIS614 |
| E | SER13 |
| E | PHE14 |
| A | TYR569 |
| A | GLY570 |
| A | GLY603 |
| A | LYS604 |
| B | HOH144 |
| B | ASP624 |
| B | GLY625 |
| B | ASN626 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 7 |
| Chain | Residue |
| A | HOH62 |
| A | HOH129 |
| A | LYS501 |
| A | TYR536 |
| A | ARG538 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 14 |
| Chain | Residue |
| A | VAL514 |
| A | HIS548 |
| D | VAL514 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 19 |
| Chain | Residue |
| A | EDO20 |
| A | HOH120 |
| A | VAL584 |
| A | VAL585 |
| A | ASN586 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 20 |
| Chain | Residue |
| A | EDO19 |
| A | ASN586 |
| B | GLN547 |
| C | LYS621 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2 |
| Chain | Residue |
| A | HOH371 |
| A | LYS501 |
| A | TYR536 |
| B | LYS592 |
| B | ARG623 |
| E | GLN12 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE P6G B 4 |
| Chain | Residue |
| B | GLN613 |
| B | HIS614 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1 |
| Chain | Residue |
| B | HOH428 |
| B | VAL584 |
| B | VAL585 |
| B | ASN586 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 656 |
| Chain | Residue |
| B | EDO11 |
| B | HOH332 |
| B | GLY603 |
| B | LYS604 |
| C | GLU606 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 5 |
| Chain | Residue |
| B | ARG525 |
| F | GLY7 |
| F | CYS8 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 11 |
| Chain | Residue |
| B | HOH149 |
| B | TYR569 |
| B | GLY570 |
| B | LYS604 |
| B | EDO656 |
| F | SER13 |
| F | PHE14 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 13 |
| Chain | Residue |
| B | PRO618 |
| B | THR627 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 15 |
| Chain | Residue |
| B | HOH113 |
| B | HOH251 |
| B | LYS501 |
| B | TYR536 |
| B | ARG538 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 16 |
| Chain | Residue |
| B | HOH104 |
| B | HOH113 |
| B | ARG538 |
| C | HOH302 |
| C | SER540 |
| F | ARG15 |
| site_id | BC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 B 6 |
| Chain | Residue |
| B | HOH9 |
| B | HOH149 |
| B | ASN537 |
| B | GLY570 |
| B | HIS571 |
| B | TYR572 |
| B | GLU573 |
| C | HOH5 |
| F | HOH247 |
| G | ARG15 |
| G | HOH239 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE P6G C 2 |
| Chain | Residue |
| B | GLU606 |
| C | HOH393 |
| C | TYR569 |
| C | GLY570 |
| C | GLY603 |
| C | LYS604 |
| G | SER13 |
| G | PHE14 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE P6G C 3 |
| Chain | Residue |
| B | TYR605 |
| B | ASP638 |
| B | ASP641 |
| C | HOH347 |
| C | ASP638 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 656 |
| Chain | Residue |
| G | ARG15 |
| G | HOH100 |
| B | SER540 |
| C | ARG538 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 657 |
| Chain | Residue |
| C | TYR572 |
| C | GLU606 |
| C | GLN613 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 17 |
| Chain | Residue |
| A | ARG520 |
| C | HOH319 |
| C | GLN613 |
| C | HIS614 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 18 |
| Chain | Residue |
| C | LEU497 |
| C | GLU498 |
| C | ASP521 |
| C | PHE532 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 6 |
| Chain | Residue |
| D | HOH314 |
| D | GLU498 |
| D | ASP521 |
| D | PHE532 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 8 |
| Chain | Residue |
| D | HOH80 |
| D | HOH306 |
| D | LYS501 |
| D | TYR536 |
| D | ARG538 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 10 |
| Chain | Residue |
| D | HOH213 |
| D | HOH320 |
| D | ALA499 |
| D | ASP504 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 12 |
| Chain | Residue |
| D | HOH382 |
| D | LYS592 |
| D | ARG623 |
| site_id | CC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1 |
| Chain | Residue |
| D | HOH4 |
| D | HOH43 |
| D | HOH69 |
| D | HOH86 |
| D | HOH245 |
| D | ASN537 |
| D | GLY570 |
| D | HIS571 |
| D | TYR572 |
| D | GLU573 |
| E | ARG15 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 3 |
| Chain | Residue |
| D | HOH31 |
| D | HOH77 |
| D | HOH235 |
| D | ASN537 |
| D | VAL539 |
| D | SER540 |
| E | ARG15 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 F 17 |
| Chain | Residue |
| B | HOH330 |
| B | TYR569 |
| B | LYS602 |
| F | GLN12 |
| F | SER13 |
| F | HOH232 |
| site_id | DC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO G 17 |
| Chain | Residue |
| C | SER568 |
| C | GLU598 |
| G | ARG6 |
| G | GLY7 |
| G | CYS8 |
| G | ALA9 |
| G | HOH101 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 H 17 |
| Chain | Residue |
| D | TYR569 |
| D | LYS602 |
| H | GLN12 |
| H | SER13 |
| H | HOH223 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 128 |
| Details | Repeat: {"description":"ANK 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 128 |
| Details | Repeat: {"description":"ANK 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 128 |
| Details | Repeat: {"description":"ANK 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 32 |
| Details | Region: {"description":"HIF1AN-binding","evidences":[{"source":"PubMed","id":"21251231","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"(3S)-3-hydroxyasparagine; by HIF1AN; partial","evidences":[{"source":"PubMed","id":"18936059","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"(3S)-3-hydroxyhistidine; by HIF1AN; partial","evidences":[{"source":"PubMed","id":"21251231","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
