Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3TVI

Crystal structure of Clostridium acetobutylicum aspartate kinase (CaAK): An important allosteric enzyme for industrial amino acids production

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004072	molecular_function	aspartate kinase activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0009085	biological_process	lysine biosynthetic process
A	0009088	biological_process	threonine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0009090	biological_process	homoserine biosynthetic process
A	0016301	molecular_function	kinase activity
B	0004072	molecular_function	aspartate kinase activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0008652	biological_process	amino acid biosynthetic process
B	0009085	biological_process	lysine biosynthetic process
B	0009088	biological_process	threonine biosynthetic process
B	0009089	biological_process	lysine biosynthetic process via diaminopimelate
B	0009090	biological_process	homoserine biosynthetic process
B	0016301	molecular_function	kinase activity
C	0004072	molecular_function	aspartate kinase activity
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0008652	biological_process	amino acid biosynthetic process
C	0009085	biological_process	lysine biosynthetic process
C	0009088	biological_process	threonine biosynthetic process
C	0009089	biological_process	lysine biosynthetic process via diaminopimelate
C	0009090	biological_process	homoserine biosynthetic process
C	0016301	molecular_function	kinase activity
D	0004072	molecular_function	aspartate kinase activity
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0008652	biological_process	amino acid biosynthetic process
D	0009085	biological_process	lysine biosynthetic process
D	0009088	biological_process	threonine biosynthetic process
D	0009089	biological_process	lysine biosynthetic process via diaminopimelate
D	0009090	biological_process	homoserine biosynthetic process
D	0016301	molecular_function	kinase activity
E	0004072	molecular_function	aspartate kinase activity
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0008652	biological_process	amino acid biosynthetic process
E	0009085	biological_process	lysine biosynthetic process
E	0009088	biological_process	threonine biosynthetic process
E	0009089	biological_process	lysine biosynthetic process via diaminopimelate
E	0009090	biological_process	homoserine biosynthetic process
E	0016301	molecular_function	kinase activity
F	0004072	molecular_function	aspartate kinase activity
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0008652	biological_process	amino acid biosynthetic process
F	0009085	biological_process	lysine biosynthetic process
F	0009088	biological_process	threonine biosynthetic process
F	0009089	biological_process	lysine biosynthetic process via diaminopimelate
F	0009090	biological_process	homoserine biosynthetic process
F	0016301	molecular_function	kinase activity
G	0004072	molecular_function	aspartate kinase activity
G	0005524	molecular_function	ATP binding
G	0005829	cellular_component	cytosol
G	0008652	biological_process	amino acid biosynthetic process
G	0009085	biological_process	lysine biosynthetic process
G	0009088	biological_process	threonine biosynthetic process
G	0009089	biological_process	lysine biosynthetic process via diaminopimelate
G	0009090	biological_process	homoserine biosynthetic process
G	0016301	molecular_function	kinase activity
H	0004072	molecular_function	aspartate kinase activity
H	0005524	molecular_function	ATP binding
H	0005829	cellular_component	cytosol
H	0008652	biological_process	amino acid biosynthetic process
H	0009085	biological_process	lysine biosynthetic process
H	0009088	biological_process	threonine biosynthetic process
H	0009089	biological_process	lysine biosynthetic process via diaminopimelate
H	0009090	biological_process	homoserine biosynthetic process
H	0016301	molecular_function	kinase activity
I	0004072	molecular_function	aspartate kinase activity
I	0005524	molecular_function	ATP binding
I	0005829	cellular_component	cytosol
I	0008652	biological_process	amino acid biosynthetic process
I	0009085	biological_process	lysine biosynthetic process
I	0009088	biological_process	threonine biosynthetic process
I	0009089	biological_process	lysine biosynthetic process via diaminopimelate
I	0009090	biological_process	homoserine biosynthetic process
I	0016301	molecular_function	kinase activity
J	0004072	molecular_function	aspartate kinase activity
J	0005524	molecular_function	ATP binding
J	0005829	cellular_component	cytosol
J	0008652	biological_process	amino acid biosynthetic process
J	0009085	biological_process	lysine biosynthetic process
J	0009088	biological_process	threonine biosynthetic process
J	0009089	biological_process	lysine biosynthetic process via diaminopimelate
J	0009090	biological_process	homoserine biosynthetic process
J	0016301	molecular_function	kinase activity
K	0004072	molecular_function	aspartate kinase activity
K	0005524	molecular_function	ATP binding
K	0005829	cellular_component	cytosol
K	0008652	biological_process	amino acid biosynthetic process
K	0009085	biological_process	lysine biosynthetic process
K	0009088	biological_process	threonine biosynthetic process
K	0009089	biological_process	lysine biosynthetic process via diaminopimelate
K	0009090	biological_process	homoserine biosynthetic process
K	0016301	molecular_function	kinase activity
L	0004072	molecular_function	aspartate kinase activity
L	0005524	molecular_function	ATP binding
L	0005829	cellular_component	cytosol
L	0008652	biological_process	amino acid biosynthetic process
L	0009085	biological_process	lysine biosynthetic process
L	0009088	biological_process	threonine biosynthetic process
L	0009089	biological_process	lysine biosynthetic process via diaminopimelate
L	0009090	biological_process	homoserine biosynthetic process
L	0016301	molecular_function	kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ASP A 451

Chain	Residue
A	LYS7
A	SER38
A	GLU116
A	PHE170
A	GLY186
A	SER187

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LYS A 501

Chain	Residue
A	SER333
A	GLY334
A	VAL335
B	SER327
B	PHE328
B	GLU329
A	GLY312
A	PHE313
A	CYS314

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LYS B 502

Chain	Residue
A	SER327
A	PHE328
A	GLU329
B	LEU307
B	ASN308
B	GLU310
B	GLY312
B	PHE313
B	CYS314
B	GLY334
B	VAL335
B	SER337

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LYS C 503

Chain	Residue
C	ASN308
C	VAL311
C	PHE313
C	CYS314
C	SER333
C	GLY334
D	TYR239
D	PHE328
D	GLU329

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ASP D 454

Chain	Residue
D	SER38
D	GLU116
D	GLY186
D	SER187

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LYS D 504

Chain	Residue
C	SER327
C	PHE328
D	ASN308
D	PHE313
D	CYS314
D	SER333
D	GLY334
D	VAL335
D	SER337

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ASP E 455

Chain	Residue
E	THR51
E	GLU116
E	PHE170
E	GLY186
E	SER187

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ASP G 457

Chain	Residue
G	ALA39
G	THR51
G	GLU116
G	GLY186
G	SER187

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LYS G 507

Chain	Residue
G	LEU307
G	ASN308
G	GLU310
G	GLY312
G	PHE313
G	CYS314
G	SER333
G	GLY334
H	PHE328

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ASP H 458

Chain	Residue
H	SER38
H	GLU116
H	PHE170
H	GLY186
H	SER187

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE LYS H 508

Chain	Residue
G	PHE328
G	GLU329
H	ASN308
H	GLU310
H	GLY312
H	PHE313
H	CYS314
H	GLY334

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ASP I 459

Chain	Residue
I	SER38
I	GLU116
I	PHE170
I	GLY186
I	SER187

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ASP L 462

Chain	Residue
L	SER38
L	THR51
L	GLU116
L	PHE170
L	GLY186
L	SER187

Functional Information from PROSITE/UniProt

site_id	PS00324
Number of Residues	9
Details	ASPARTOKINASE Aspartokinase signature. VtKFGGSSL

Chain	Residue	Details
A	VAL5-LEU13

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)