3TVC

Human MMP13 in complex with L-glutamate motif inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	E3P1
A	HIS222
A	HIS226
A	HIS232

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	HIS172
A	ASP174
A	HIS187
A	HIS200

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 503

Chain	Residue
A	ASP128
A	ASP203
A	GLU205
A	HOH65

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 504

Chain	Residue
A	ASP179
A	GLY180
A	SER182
A	LEU184
A	ASP202
A	GLU205

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 505

Chain	Residue
A	HOH14
A	HOH63
A	ASP162
A	ASN194
A	GLY196
A	ASP198

---

site_id	AC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE E3P A 1

Chain	Residue
A	HOH58
A	HIS157
A	LEU184
A	LEU185
A	ALA186
A	LEU218
A	HIS222
A	GLU223
A	HIS226
A	HIS232
A	LEU239
A	PHE241
A	PRO242
A	ILE243
A	TYR244
A	THR245
A	THR247
A	ZN501

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG A 273

Chain	Residue
A	ASN117
A	ASN152
A	THR154
A	LYS212
A	GLY213

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG A 2

Chain	Residue
A	HOH76
A	LYS143
A	VAL144
A	ASP147
A	PHE252

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG A 3

Chain	Residue
A	ARG109
A	LYS112
A	TRP113
A	SER114
A	PRO191
A	GLY192

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL

Chain	Residue	Details
A	VAL219-LEU228

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:23913860

Chain	Residue	Details
A	GLU223

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305

Chain	Residue	Details
A	ASP128
A	ASP202
A	ASP203
A	GLU205
A	ASP162
A	ASP179
A	GLY180
A	SER182
A	LEU184
A	ASN194
A	GLY196
A	ASP198

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860

Chain	Residue	Details
A	HIS172
A	ASP174
A	HIS187
A	HIS200
A	HIS222
A	HIS226
A	HIS232
A	MET240

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8576151

Chain	Residue	Details
A	ASN117

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN152

---