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3TVC

Human MMP13 in complex with L-glutamate motif inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0031012cellular_componentextracellular matrix
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 501
ChainResidue
AE3P1
AHIS222
AHIS226
AHIS232

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 502
ChainResidue
AHIS172
AASP174
AHIS187
AHIS200

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 503
ChainResidue
AASP128
AASP203
AGLU205
AHOH65

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 504
ChainResidue
AASP179
AGLY180
ASER182
ALEU184
AASP202
AGLU205

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 505
ChainResidue
AHOH14
AHOH63
AASP162
AASN194
AGLY196
AASP198

site_idAC6
Number of Residues18
DetailsBINDING SITE FOR RESIDUE E3P A 1
ChainResidue
AHOH58
AHIS157
ALEU184
ALEU185
AALA186
ALEU218
AHIS222
AGLU223
AHIS226
AHIS232
ALEU239
APHE241
APRO242
AILE243
ATYR244
ATHR245
ATHR247
AZN501

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PEG A 273
ChainResidue
AASN117
AASN152
ATHR154
ALYS212
AGLY213

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PEG A 2
ChainResidue
AHOH76
ALYS143
AVAL144
AASP147
APHE252

site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PEG A 3
ChainResidue
AARG109
ALYS112
ATRP113
ASER114
APRO191
AGLY192

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL
ChainResidueDetails
AVAL219-LEU228

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues70
DetailsRegion: {"description":"Interaction with TIMP2"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsActive site: {"evidences":[{"source":"PubMed","id":"23913860","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10926524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10986126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15734645","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15780611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17196980","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17623656","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19422229","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20005097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20726512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22689580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23810497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23913860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8969305","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10926524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10986126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15734645","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15780611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17196980","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17623656","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19422229","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20005097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20726512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22689580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23810497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23913860","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8576151","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

243531

PDB entries from 2025-10-22

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