Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE HEC A 1004 |
| Chain | Residue |
| A | HIS113 |
| A | LYS188 |
| A | ARG242 |
| A | CYS299 |
| A | HIS300 |
| A | TYR303 |
| A | CYS305 |
| A | PHE327 |
| A | HIS361 |
| A | ASN486 |
| A | SO3526 |
| A | ALA114 |
| A | CO528 |
| A | HOH536 |
| A | HOH543 |
| A | HOH568 |
| A | HOH596 |
| A | HOH646 |
| A | HEC1006 |
| A | PRO116 |
| A | ASP125 |
| A | HIS126 |
| A | VAL129 |
| A | ARG131 |
| A | CYS184 |
| A | CYS187 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE HEC A 1005 |
| Chain | Residue |
| A | CYS66 |
| A | HIS70 |
| A | GLN73 |
| A | PHE77 |
| A | ASN226 |
| A | CYS227 |
| A | CYS230 |
| A | HIS231 |
| A | ALA290 |
| A | MET384 |
| A | ARG386 |
| A | TYR395 |
| A | THR396 |
| A | HIS398 |
| A | HOH573 |
| A | HOH753 |
| A | HEC1003 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE HEC A 1006 |
| Chain | Residue |
| A | SER84 |
| A | PRO116 |
| A | ARG117 |
| A | HIS119 |
| A | PHE121 |
| A | MET122 |
| A | ASP125 |
| A | CYS187 |
| A | LYS188 |
| A | VAL225 |
| A | MET229 |
| A | MET295 |
| A | CYS296 |
| A | CYS299 |
| A | HIS300 |
| A | CYS379 |
| A | HIS383 |
| A | PRO400 |
| A | HOH548 |
| A | HOH810 |
| A | HOH897 |
| A | HOH899 |
| A | HEC1004 |
| A | HEC1007 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE HEC A 1007 |
| Chain | Residue |
| A | HIS300 |
| A | LEU364 |
| A | PHE367 |
| A | HIS372 |
| A | VAL377 |
| A | THR378 |
| A | CYS379 |
| A | CYS382 |
| A | HIS383 |
| A | THR402 |
| A | ARG404 |
| A | ILE427 |
| A | LYS431 |
| A | ASN486 |
| A | PHE490 |
| A | HIS491 |
| A | GOL531 |
| A | HOH548 |
| A | HOH616 |
| A | HOH761 |
| A | HOH810 |
| A | HEC1006 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE HEC A 1008 |
| Chain | Residue |
| A | TRP418 |
| A | ILE427 |
| A | PHE490 |
| A | SER141 |
| A | TRP142 |
| A | GLN143 |
| A | THR371 |
| A | HIS372 |
| A | PRO403 |
| A | ALA410 |
| A | CYS411 |
| A | CYS414 |
| A | HIS415 |
| site_id | AC6 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEC A 1002 |
| Chain | Residue |
| A | CYS14 |
| A | TYR15 |
| A | HIS18 |
| A | ILE21 |
| A | HIS25 |
| A | VAL33 |
| A | ASN34 |
| A | CYS35 |
| A | CYS38 |
| A | HIS39 |
| A | ILE193 |
| A | LEU194 |
| A | TYR228 |
| A | PRO233 |
| A | HIS234 |
| A | ARG239 |
| A | PHE274 |
| A | ARG276 |
| A | ARG282 |
| A | HOH599 |
| A | HOH878 |
| A | HEC1001 |
| A | HEC1003 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE HEC A 1003 |
| Chain | Residue |
| A | LYS29 |
| A | HIS30 |
| A | VAL33 |
| A | HIS37 |
| A | ALA65 |
| A | CYS66 |
| A | SER68 |
| A | CYS69 |
| A | HIS70 |
| A | CYS227 |
| A | HIS231 |
| A | THR236 |
| A | HOH788 |
| A | HEC1002 |
| A | HEC1005 |
| site_id | AC8 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE HEC A 1001 |
| Chain | Residue |
| A | GLN13 |
| A | CYS14 |
| A | CYS17 |
| A | HIS18 |
| A | HIS39 |
| A | HIS44 |
| A | VAL45 |
| A | ALA48 |
| A | SER49 |
| A | ALA50 |
| A | ARG51 |
| A | ARG51 |
| A | ARG52 |
| A | MET53 |
| A | ARG56 |
| A | PRO57 |
| A | THR59 |
| A | LEU194 |
| A | GLN275 |
| A | ARG276 |
| A | SO4534 |
| A | HOH575 |
| A | HOH662 |
| A | HOH715 |
| A | HOH815 |
| A | HOH878 |
| A | HEC1002 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO3 A 526 |
| Chain | Residue |
| A | PHE109 |
| A | ARG131 |
| A | TYR303 |
| A | GLN360 |
| A | HIS361 |
| A | HOH543 |
| A | HOH811 |
| A | HEC1004 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 527 |
| Chain | Residue |
| A | GLU302 |
| A | TYR303 |
| A | LYS358 |
| A | GLN360 |
| A | HOH555 |
| A | HOH670 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CO A 528 |
| Chain | Residue |
| A | HIS113 |
| A | HOH536 |
| A | HOH543 |
| A | HOH596 |
| A | HOH646 |
| A | HEC1004 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CO A 529 |
| Chain | Residue |
| A | HIS85 |
| A | GLU88 |
| A | HOH766 |
| A | HOH771 |
| A | HOH792 |
| A | HOH866 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 530 |
| Chain | Residue |
| A | LYS393 |
| A | GLU394 |
| B | ARG153 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 531 |
| Chain | Residue |
| A | LYS90 |
| A | ARG96 |
| A | GLU115 |
| A | PRO116 |
| A | ASN486 |
| A | HOH589 |
| A | HOH616 |
| A | HOH810 |
| A | HEC1007 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 532 |
| Chain | Residue |
| A | MET406 |
| A | MET407 |
| A | ASN408 |
| A | ARG409 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 533 |
| Chain | Residue |
| A | THR59 |
| A | HIS60 |
| A | THR61 |
| A | SER62 |
| A | HIS223 |
| A | HOH805 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 534 |
| Chain | Residue |
| A | HIS18 |
| A | THR19 |
| A | GLN20 |
| A | ILE21 |
| A | PHE274 |
| A | HOH878 |
| A | HEC1001 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 535 |
| Chain | Residue |
| A | ARG170 |
| A | ARG171 |
| site_id | CC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE HEC B 1004 |
| Chain | Residue |
| B | HIS113 |
| B | ALA114 |
| B | PRO116 |
| B | ASP125 |
| B | HIS126 |
| B | VAL129 |
| B | ARG131 |
| B | ALA179 |
| B | CYS184 |
| B | CYS187 |
| B | LYS188 |
| B | ARG242 |
| B | CYS299 |
| B | HIS300 |
| B | TYR303 |
| B | CYS305 |
| B | PHE327 |
| B | HIS361 |
| B | ASN486 |
| B | SO3526 |
| B | CO528 |
| B | HOH544 |
| B | HOH551 |
| B | HOH576 |
| B | HOH604 |
| B | HOH652 |
| B | HOH825 |
| B | HEC1006 |
| site_id | CC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE HEC B 1005 |
| Chain | Residue |
| B | CYS66 |
| B | HIS70 |
| B | GLN73 |
| B | PHE77 |
| B | ASN226 |
| B | CYS227 |
| B | CYS230 |
| B | HIS231 |
| B | ARG386 |
| B | TYR395 |
| B | THR396 |
| B | HIS398 |
| B | HOH756 |
| B | HEC1003 |
| site_id | CC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEC B 1006 |
| Chain | Residue |
| B | SER84 |
| B | PRO116 |
| B | ARG117 |
| B | SER118 |
| B | HIS119 |
| B | PHE121 |
| B | MET122 |
| B | ASP125 |
| B | CYS187 |
| B | LYS188 |
| B | MET229 |
| B | MET295 |
| B | CYS296 |
| B | CYS299 |
| B | HIS300 |
| B | HIS383 |
| B | PRO400 |
| B | HOH541 |
| B | HOH556 |
| B | HOH813 |
| B | HOH817 |
| B | HEC1004 |
| B | HEC1007 |
| site_id | CC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEC B 1007 |
| Chain | Residue |
| B | HIS300 |
| B | GLU363 |
| B | LEU364 |
| B | PHE367 |
| B | HIS372 |
| B | VAL377 |
| B | THR378 |
| B | CYS379 |
| B | CYS382 |
| B | HIS383 |
| B | THR402 |
| B | ARG404 |
| B | ILE427 |
| B | LYS431 |
| B | ASN486 |
| B | PHE490 |
| B | HIS491 |
| B | GOL531 |
| B | HOH556 |
| B | HOH624 |
| B | HOH764 |
| B | HOH897 |
| B | HEC1006 |
| site_id | CC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE HEC B 1008 |
| Chain | Residue |
| B | SER141 |
| B | TRP142 |
| B | GLN143 |
| B | THR371 |
| B | HIS372 |
| B | ASN375 |
| B | VAL377 |
| B | PRO403 |
| B | ALA410 |
| B | CYS411 |
| B | CYS414 |
| B | HIS415 |
| B | TRP418 |
| B | ILE427 |
| B | PHE490 |
| B | HOH863 |
| site_id | CC6 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE HEC B 1002 |
| Chain | Residue |
| B | CYS14 |
| B | TYR15 |
| B | HIS18 |
| B | ILE21 |
| B | HIS25 |
| B | VAL33 |
| B | ASN34 |
| B | CYS35 |
| B | CYS38 |
| B | HIS39 |
| B | THR59 |
| B | ILE193 |
| B | LEU194 |
| B | TYR228 |
| B | PRO233 |
| B | HIS234 |
| B | ARG239 |
| B | PHE274 |
| B | ARG276 |
| B | ARG282 |
| B | HOH607 |
| B | HOH820 |
| B | HEC1001 |
| B | HEC1003 |
| site_id | CC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE HEC B 1003 |
| Chain | Residue |
| B | LYS29 |
| B | HIS30 |
| B | VAL33 |
| B | HIS37 |
| B | ALA65 |
| B | CYS66 |
| B | CYS69 |
| B | HIS70 |
| B | CYS227 |
| B | HIS231 |
| B | THR236 |
| B | HOH790 |
| B | HEC1002 |
| B | HEC1005 |
| site_id | CC8 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEC B 1001 |
| Chain | Residue |
| B | GLN13 |
| B | CYS14 |
| B | CYS17 |
| B | HIS18 |
| B | HIS39 |
| B | HIS44 |
| B | VAL45 |
| B | ALA48 |
| B | SER49 |
| B | ALA50 |
| B | ARG52 |
| B | MET53 |
| B | ARG56 |
| B | PRO57 |
| B | THR59 |
| B | LEU194 |
| B | ARG276 |
| B | GLY277 |
| B | HOH583 |
| B | HOH667 |
| B | HOH791 |
| B | HOH821 |
| B | HEC1002 |
| site_id | CC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO3 B 526 |
| Chain | Residue |
| B | PHE109 |
| B | ARG131 |
| B | TYR303 |
| B | GLN360 |
| B | HIS361 |
| B | HOH551 |
| B | HOH814 |
| B | HOH825 |
| B | HEC1004 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 527 |
| Chain | Residue |
| B | GLU302 |
| B | TYR303 |
| B | LYS358 |
| B | GLN360 |
| B | HOH563 |
| B | HOH675 |
| site_id | DC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CO B 528 |
| Chain | Residue |
| B | HIS113 |
| B | HOH544 |
| B | HOH551 |
| B | HOH604 |
| B | HOH652 |
| B | HOH825 |
| B | HEC1004 |
| site_id | DC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CO B 529 |
| Chain | Residue |
| B | HIS85 |
| B | GLU88 |
| B | HOH769 |
| B | HOH774 |
| B | HOH794 |
| B | HOH899 |
| site_id | DC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 530 |
| Chain | Residue |
| A | ARG153 |
| B | LYS393 |
| B | GLU394 |
| B | HOH885 |
| site_id | DC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 531 |
| Chain | Residue |
| B | LYS90 |
| B | ARG96 |
| B | GLU115 |
| B | PRO116 |
| B | ASN486 |
| B | HOH597 |
| B | HOH813 |
| B | HEC1007 |
| site_id | DC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 532 |
| Chain | Residue |
| B | TYR259 |
| B | ASN331 |
| B | TRP368 |
| B | HOH546 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 533 |
| Chain | Residue |
| B | MET406 |
| B | MET407 |
| B | ASN408 |
| B | ARG409 |
| site_id | DC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 534 |
| Chain | Residue |
| B | HIS60 |
| B | THR61 |
| B | SER62 |
| B | HIS223 |
| B | HOH808 |
| B | HOH880 |
| site_id | DC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 535 |
| Chain | Residue |
| B | ARG170 |
| B | ARG171 |
