Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3TSR

X-ray structure of mouse ribonuclease inhibitor complexed with mouse ribonuclease 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0004519	molecular_function	endonuclease activity
A	0004522	molecular_function	ribonuclease A activity
A	0004540	molecular_function	RNA nuclease activity
A	0005576	cellular_component	extracellular region
A	0009617	biological_process	response to bacterium
A	0016829	molecular_function	lyase activity
A	0050830	biological_process	defense response to Gram-positive bacterium
B	0003676	molecular_function	nucleic acid binding
B	0004519	molecular_function	endonuclease activity
B	0004522	molecular_function	ribonuclease A activity
B	0004540	molecular_function	RNA nuclease activity
B	0005576	cellular_component	extracellular region
B	0009617	biological_process	response to bacterium
B	0016829	molecular_function	lyase activity
B	0050830	biological_process	defense response to Gram-positive bacterium
C	0003676	molecular_function	nucleic acid binding
C	0004519	molecular_function	endonuclease activity
C	0004522	molecular_function	ribonuclease A activity
C	0004540	molecular_function	RNA nuclease activity
C	0005576	cellular_component	extracellular region
C	0009617	biological_process	response to bacterium
C	0016829	molecular_function	lyase activity
C	0050830	biological_process	defense response to Gram-positive bacterium
D	0003676	molecular_function	nucleic acid binding
D	0004519	molecular_function	endonuclease activity
D	0004522	molecular_function	ribonuclease A activity
D	0004540	molecular_function	RNA nuclease activity
D	0005576	cellular_component	extracellular region
D	0009617	biological_process	response to bacterium
D	0016829	molecular_function	lyase activity
D	0050830	biological_process	defense response to Gram-positive bacterium
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0008428	molecular_function	ribonuclease inhibitor activity
E	0016477	biological_process	cell migration
E	0030027	cellular_component	lamellipodium
E	0032311	cellular_component	angiogenin-PRI complex
E	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
E	0045765	biological_process	regulation of angiogenesis
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0008428	molecular_function	ribonuclease inhibitor activity
F	0016477	biological_process	cell migration
F	0030027	cellular_component	lamellipodium
F	0032311	cellular_component	angiogenin-PRI complex
F	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
F	0045765	biological_process	regulation of angiogenesis
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005886	cellular_component	plasma membrane
G	0008428	molecular_function	ribonuclease inhibitor activity
G	0016477	biological_process	cell migration
G	0030027	cellular_component	lamellipodium
G	0032311	cellular_component	angiogenin-PRI complex
G	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
G	0045765	biological_process	regulation of angiogenesis
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005886	cellular_component	plasma membrane
H	0008428	molecular_function	ribonuclease inhibitor activity
H	0016477	biological_process	cell migration
H	0030027	cellular_component	lamellipodium
H	0032311	cellular_component	angiogenin-PRI complex
H	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
H	0045765	biological_process	regulation of angiogenesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 126

Chain	Residue
A	GLN29
A	HOH631
E	ASN89

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG E 457

Chain	Residue
E	LYS269
E	ASP270
E	ARG273
H	GLU94
H	ALA95
H	LEU127

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO E 458

Chain	Residue
E	SER231
E	ASN232
E	LYS233
E	GLU260
E	ASP262

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO E 459

Chain	Residue
E	GLU8
E	GLN9
E	ASP32

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO F 457

Chain	Residue
F	SER231
F	ASN232
F	LYS233
F	GLU260
F	ASP262

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO F 458

Chain	Residue
B	GLN29
F	ASN89
F	HOH926

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO F 459

Chain	Residue
B	ARG33
F	GLN9

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO G 457

Chain	Residue
G	SER231
G	ASN232
G	LYS233
G	GLU260

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO G 458

Chain	Residue
G	GLU62
G	ASN89

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO G 459

Chain	Residue
G	SER383
G	HOH870

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO G 460

Chain	Residue
G	CYS7
G	GLN9
G	ASP32

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO H 457

Chain	Residue
H	ASN61
H	GLU62
H	ASN89

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO H 458

Chain	Residue
H	SER383

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO H 459

Chain	Residue
D	ARG33
H	GLN9

Functional Information from PROSITE/UniProt

site_id	PS00127
Number of Residues	7
Details	RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF

Chain	Residue	Details
A	CYS41-PHE47

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N-acetylmethionine => ECO:0000250\|UniProtKB:P10775

Chain	Residue	Details
E	MET1
F	MET1
G	MET1
H	MET1

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P13489

Chain	Residue	Details
E	SER86
F	SER86
G	SER86
H	SER86

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
D	LYS8
D	ARG11
D	LYS42
D	LYS67
A	LYS8
A	ARG11
A	LYS42
A	LYS67
B	LYS8
B	ARG11
B	LYS42
B	LYS67
C	LYS8
C	ARG11
C	LYS42
C	LYS67

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)