3TR9
Structure of a dihydropteroate synthase (folP) in complex with pteroic acid from Coxiella burnetii
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004156 | molecular_function | dihydropteroate synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0042558 | biological_process | pteridine-containing compound metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004156 | molecular_function | dihydropteroate synthase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0042558 | biological_process | pteridine-containing compound metabolic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004156 | molecular_function | dihydropteroate synthase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0042558 | biological_process | pteridine-containing compound metabolic process |
| C | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| C | 0046656 | biological_process | folic acid biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004156 | molecular_function | dihydropteroate synthase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0042558 | biological_process | pteridine-containing compound metabolic process |
| D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| D | 0046656 | biological_process | folic acid biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE PT1 A 1001 |
| Chain | Residue |
| A | ASP111 |
| A | LEU232 |
| A | GLY234 |
| A | LYS238 |
| A | SER239 |
| A | ARG272 |
| A | CL315 |
| A | HOH321 |
| A | HOH351 |
| A | HOH376 |
| A | ASN130 |
| A | GLN132 |
| A | CYS152 |
| A | MSE154 |
| A | ASP199 |
| A | GLY203 |
| A | GLN204 |
| A | TYR207 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 315 |
| Chain | Residue |
| A | ASN35 |
| A | ARG272 |
| A | HIS274 |
| A | PT11001 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA A 316 |
| Chain | Residue |
| A | ASP111 |
| A | THR112 |
| A | SER113 |
| A | ASN130 |
| A | ASP131 |
| A | GLN132 |
| A | HOH427 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 317 |
| Chain | Residue |
| A | ILE191 |
| A | SER192 |
| A | ARG195 |
| A | HOH361 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PT1 B 1001 |
| Chain | Residue |
| B | ASP111 |
| B | ASN130 |
| B | GLN132 |
| B | CYS152 |
| B | MSE154 |
| B | ASP199 |
| B | GLY203 |
| B | GLN204 |
| B | TYR207 |
| B | GLY234 |
| B | LYS238 |
| B | SER239 |
| B | ARG272 |
| B | CL315 |
| B | HOH316 |
| B | HOH330 |
| B | HOH350 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 315 |
| Chain | Residue |
| B | ASN35 |
| B | ARG272 |
| B | HIS274 |
| B | PT11001 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PT1 C 1001 |
| Chain | Residue |
| C | ASP111 |
| C | ASN130 |
| C | GLN132 |
| C | CYS152 |
| C | MSE154 |
| C | ASP199 |
| C | GLY203 |
| C | GLN204 |
| C | TYR207 |
| C | GLY234 |
| C | LYS238 |
| C | SER239 |
| C | ARG272 |
| C | HOH316 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA C 315 |
| Chain | Residue |
| C | GLN11 |
| C | VAL264 |
| C | GLY267 |
| C | ALA268 |
| C | HOH326 |
| site_id | AC9 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PT1 D 1001 |
| Chain | Residue |
| C | HOH424 |
| D | PRO75 |
| D | ASP111 |
| D | ASN130 |
| D | GLN132 |
| D | CYS152 |
| D | MSE154 |
| D | ASP199 |
| D | GLY203 |
| D | GLN204 |
| D | TYR207 |
| D | GLY234 |
| D | LYS238 |
| D | SER239 |
| D | ARG272 |
| D | HOH315 |
Functional Information from PROSITE/UniProt
| site_id | PS00793 |
| Number of Residues | 14 |
| Details | DHPS_2 Dihydropteroate synthase signature 2. GAdILDIGGeaTnP |
| Chain | Residue | Details |
| A | GLY62-PRO75 |
