3TNF

LidA from Legionella in complex with active Rab8a

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 199

Chain	Residue
A	THR22
A	THR40
A	ASP63
A	THR64
A	GNP200

---

site_id	AC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE GNP A 200

Chain	Residue
A	LYS21
A	THR22
A	CYS23
A	PHE33
A	ASN34
A	SER35
A	PHE37
A	SER39
A	THR40
A	GLY66
A	ASN121
A	LYS122
A	ASP124
A	VAL125
A	SER151
A	ALA152
A	LYS153
A	HOH180
A	HOH183
A	MG199
B	HOH62
B	TYR532
A	SER17
A	GLY18
A	VAL19
A	GLY20

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD A 1

Chain	Residue
A	ARG71
A	TRP102
A	ASN105

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD B 2

Chain	Residue
B	LEU254
B	GLU259
B	LEU334
B	LYS335
B	ALA393
B	LEU394

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD B 3

Chain	Residue
B	GLY233
B	LEU236
B	GLU237
B	THR550
B	HIS553

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD A 177

Chain	Residue
A	TRP62
A	TYR77
A	ARG79
B	LEU406
B	ASN410

---

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. LLLiGDSGVGKtcV

Chain	Residue	Details
A	LEU11-VAL24

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Motif: {"description":"Switch 1","evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	17
Details	Motif: {"description":"Switch 2","evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21378754","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5SZI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21378754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21378754","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QBT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21378754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QBT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by LRRK2","evidences":[{"source":"PubMed","id":"26824392","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29125462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30209220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30398148","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---