3TLR

Crystal Structure of the tetrameric Beta-2 microglobulin DIMC20 mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0001913	biological_process	T cell mediated cytotoxicity
A	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
A	0002237	biological_process	response to molecule of bacterial origin
A	0002376	biological_process	immune system process
A	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
A	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
A	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
A	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
A	0002726	biological_process	positive regulation of T cell cytokine production
A	0005198	molecular_function	structural molecule activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005765	cellular_component	lysosomal membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006955	biological_process	immune response
A	0007608	biological_process	sensory perception of smell
A	0007611	biological_process	learning or memory
A	0009897	cellular_component	external side of plasma membrane
A	0009986	cellular_component	cell surface
A	0010038	biological_process	response to metal ion
A	0010977	biological_process	negative regulation of neuron projection development
A	0012507	cellular_component	ER to Golgi transport vesicle membrane
A	0016020	cellular_component	membrane
A	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
A	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
A	0023026	molecular_function	MHC class II protein complex binding
A	0030670	cellular_component	phagocytic vesicle membrane
A	0031901	cellular_component	early endosome membrane
A	0031902	cellular_component	late endosome membrane
A	0031905	cellular_component	early endosome lumen
A	0033077	biological_process	T cell differentiation in thymus
A	0033572	biological_process	transferrin transport
A	0034756	biological_process	regulation of iron ion transport
A	0034757	biological_process	negative regulation of iron ion transport
A	0035580	cellular_component	specific granule lumen
A	0042026	biological_process	protein refolding
A	0042605	molecular_function	peptide antigen binding
A	0042612	cellular_component	MHC class I protein complex
A	0042613	cellular_component	MHC class II protein complex
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0042824	cellular_component	MHC class I peptide loading complex
A	0045646	biological_process	regulation of erythrocyte differentiation
A	0048260	biological_process	positive regulation of receptor-mediated endocytosis
A	0048261	biological_process	negative regulation of receptor-mediated endocytosis
A	0050680	biological_process	negative regulation of epithelial cell proliferation
A	0050768	biological_process	negative regulation of neurogenesis
A	0050778	biological_process	positive regulation of immune response
A	0050870	biological_process	positive regulation of T cell activation
A	0051289	biological_process	protein homotetramerization
A	0055038	cellular_component	recycling endosome membrane
A	0060586	biological_process	multicellular organismal-level iron ion homeostasis
A	0070062	cellular_component	extracellular exosome
A	0071281	biological_process	cellular response to iron ion
A	0071283	biological_process	cellular response to iron(III) ion
A	0071316	biological_process	cellular response to nicotine
A	1904724	cellular_component	tertiary granule lumen
A	1990000	biological_process	amyloid fibril formation
A	1990712	cellular_component	HFE-transferrin receptor complex
A	2000774	biological_process	positive regulation of cellular senescence
A	2000978	biological_process	negative regulation of forebrain neuron differentiation
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002376	biological_process	immune system process
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010038	biological_process	response to metal ion
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0033077	biological_process	T cell differentiation in thymus
B	0033572	biological_process	transferrin transport
B	0034756	biological_process	regulation of iron ion transport
B	0034757	biological_process	negative regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0048261	biological_process	negative regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
C	0000139	cellular_component	Golgi membrane
C	0001913	biological_process	T cell mediated cytotoxicity
C	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
C	0002237	biological_process	response to molecule of bacterial origin
C	0002376	biological_process	immune system process
C	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
C	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
C	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
C	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
C	0002726	biological_process	positive regulation of T cell cytokine production
C	0005198	molecular_function	structural molecule activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005765	cellular_component	lysosomal membrane
C	0005783	cellular_component	endoplasmic reticulum
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006955	biological_process	immune response
C	0007608	biological_process	sensory perception of smell
C	0007611	biological_process	learning or memory
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0010038	biological_process	response to metal ion
C	0010977	biological_process	negative regulation of neuron projection development
C	0012507	cellular_component	ER to Golgi transport vesicle membrane
C	0016020	cellular_component	membrane
C	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
C	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
C	0023026	molecular_function	MHC class II protein complex binding
C	0030670	cellular_component	phagocytic vesicle membrane
C	0031901	cellular_component	early endosome membrane
C	0031902	cellular_component	late endosome membrane
C	0031905	cellular_component	early endosome lumen
C	0033077	biological_process	T cell differentiation in thymus
C	0033572	biological_process	transferrin transport
C	0034756	biological_process	regulation of iron ion transport
C	0034757	biological_process	negative regulation of iron ion transport
C	0035580	cellular_component	specific granule lumen
C	0042026	biological_process	protein refolding
C	0042605	molecular_function	peptide antigen binding
C	0042612	cellular_component	MHC class I protein complex
C	0042613	cellular_component	MHC class II protein complex
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0042824	cellular_component	MHC class I peptide loading complex
C	0045646	biological_process	regulation of erythrocyte differentiation
C	0048260	biological_process	positive regulation of receptor-mediated endocytosis
C	0048261	biological_process	negative regulation of receptor-mediated endocytosis
C	0050680	biological_process	negative regulation of epithelial cell proliferation
C	0050768	biological_process	negative regulation of neurogenesis
C	0050778	biological_process	positive regulation of immune response
C	0050870	biological_process	positive regulation of T cell activation
C	0051289	biological_process	protein homotetramerization
C	0055038	cellular_component	recycling endosome membrane
C	0060586	biological_process	multicellular organismal-level iron ion homeostasis
C	0070062	cellular_component	extracellular exosome
C	0071281	biological_process	cellular response to iron ion
C	0071283	biological_process	cellular response to iron(III) ion
C	0071316	biological_process	cellular response to nicotine
C	1904724	cellular_component	tertiary granule lumen
C	1990000	biological_process	amyloid fibril formation
C	1990712	cellular_component	HFE-transferrin receptor complex
C	2000774	biological_process	positive regulation of cellular senescence
C	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0000139	cellular_component	Golgi membrane
D	0001913	biological_process	T cell mediated cytotoxicity
D	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
D	0002237	biological_process	response to molecule of bacterial origin
D	0002376	biological_process	immune system process
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
D	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
D	0002726	biological_process	positive regulation of T cell cytokine production
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005765	cellular_component	lysosomal membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0007608	biological_process	sensory perception of smell
D	0007611	biological_process	learning or memory
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0010038	biological_process	response to metal ion
D	0010977	biological_process	negative regulation of neuron projection development
D	0012507	cellular_component	ER to Golgi transport vesicle membrane
D	0016020	cellular_component	membrane
D	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
D	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
D	0023026	molecular_function	MHC class II protein complex binding
D	0030670	cellular_component	phagocytic vesicle membrane
D	0031901	cellular_component	early endosome membrane
D	0031902	cellular_component	late endosome membrane
D	0031905	cellular_component	early endosome lumen
D	0033077	biological_process	T cell differentiation in thymus
D	0033572	biological_process	transferrin transport
D	0034756	biological_process	regulation of iron ion transport
D	0034757	biological_process	negative regulation of iron ion transport
D	0035580	cellular_component	specific granule lumen
D	0042026	biological_process	protein refolding
D	0042605	molecular_function	peptide antigen binding
D	0042612	cellular_component	MHC class I protein complex
D	0042613	cellular_component	MHC class II protein complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042824	cellular_component	MHC class I peptide loading complex
D	0045646	biological_process	regulation of erythrocyte differentiation
D	0048260	biological_process	positive regulation of receptor-mediated endocytosis
D	0048261	biological_process	negative regulation of receptor-mediated endocytosis
D	0050680	biological_process	negative regulation of epithelial cell proliferation
D	0050768	biological_process	negative regulation of neurogenesis
D	0050778	biological_process	positive regulation of immune response
D	0050870	biological_process	positive regulation of T cell activation
D	0051289	biological_process	protein homotetramerization
D	0055038	cellular_component	recycling endosome membrane
D	0060586	biological_process	multicellular organismal-level iron ion homeostasis
D	0070062	cellular_component	extracellular exosome
D	0071281	biological_process	cellular response to iron ion
D	0071283	biological_process	cellular response to iron(III) ion
D	0071316	biological_process	cellular response to nicotine
D	1904724	cellular_component	tertiary granule lumen
D	1990000	biological_process	amyloid fibril formation
D	1990712	cellular_component	HFE-transferrin receptor complex
D	2000774	biological_process	positive regulation of cellular senescence
D	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 100

Chain	Residue
A	MET0
A	HIS31
C	ASP34
C	HOH108

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 101

Chain	Residue
A	GLU50
A	GLU69
D	HIS13

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 102

Chain	Residue
D	ASP98
A	GLU16
C	GLU74

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 103

Chain	Residue
A	LYS48
A	ASP96
A	ASP98

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD B 100

Chain	Residue
B	HIS13
B	HOH123
C	GLU69

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD B 101

Chain	Residue
B	MET0
B	HIS31
D	ASP34
D	HOH108

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD B 102

Chain	Residue
B	GLU47
B	GLU69
C	HIS13
C	HOH113

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD B 103

Chain	Residue
B	GLU16
B	HOH111
C	ASP98
D	GLU74

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA B 104

Chain	Residue
B	ASP96
B	ASP98

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD C 100

Chain	Residue
A	ASP34
A	HOH112
C	MET0
C	HIS31

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD D 100

Chain	Residue
B	ASP34
B	HOH109
D	MET0
D	HIS31

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD D 101

Chain	Residue
A	HIS13
D	GLU50
D	GLU69
D	HOH109

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
A	TYR78-HIS84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	352
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---