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3TK9

Crystal structure of human granzyme H

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0005615cellular_componentextracellular space
A0005764cellular_componentlysosome
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0031640biological_processkilling of cells of another organism
A0044194cellular_componentcytolytic granule
A0051604biological_processprotein maturation
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 300
ChainResidue
AARG41
AARG41
AARG43
ALYS75
ALYS75

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
ALEU55-CYS60

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. TGfkGDSGGPLV
ChainResidueDetails
ATHR191-VAL202

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system => ECO:0000250
ChainResidueDetails
AHIS59
AASN103
ASER197

site_idSWS_FT_FI2
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN66
AASN99
AASN174

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PDB entries from 2025-07-02

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