3TJX
Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant H174A
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0006106 | biological_process | fumarate metabolic process |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006222 | biological_process | UMP biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
A | 0097014 | cellular_component | ciliary plasm |
A | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0006106 | biological_process | fumarate metabolic process |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0006222 | biological_process | UMP biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0097014 | cellular_component | ciliary plasm |
B | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE FMN A 321 |
Chain | Residue |
A | ALA19 |
A | ILE194 |
A | ASN195 |
A | GLY222 |
A | GLY223 |
A | VAL226 |
A | CYS249 |
A | GLY250 |
A | GLY251 |
A | GLY272 |
A | THR273 |
A | ALA20 |
A | HOH356 |
A | HOH380 |
A | HOH460 |
A | GLY21 |
A | LYS44 |
A | SER45 |
A | ASN68 |
A | MET70 |
A | ASN128 |
A | LYS165 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 322 |
Chain | Residue |
A | ILE203 |
A | GOL324 |
A | HOH330 |
A | HOH392 |
B | LEU231 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 323 |
Chain | Residue |
A | ASP171 |
A | PHE172 |
A | ALA173 |
B | ASN199 |
B | LYS215 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL A 324 |
Chain | Residue |
A | ARG298 |
A | GOL322 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 325 |
Chain | Residue |
A | HIS160 |
A | SER161 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 326 |
Chain | Residue |
A | TYR238 |
A | HOH357 |
A | HOH601 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 327 |
Chain | Residue |
A | ARG239 |
A | THR311 |
B | GLN216 |
site_id | AC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 328 |
Chain | Residue |
A | PRO159 |
A | LYS187 |
site_id | AC9 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE FMN B 321 |
Chain | Residue |
B | ALA19 |
B | ALA20 |
B | GLY21 |
B | LYS44 |
B | SER45 |
B | ASN68 |
B | MET70 |
B | ASN128 |
B | LYS165 |
B | ILE194 |
B | ASN195 |
B | GLY222 |
B | GLY223 |
B | VAL226 |
B | CYS249 |
B | GLY250 |
B | GLY251 |
B | GLY272 |
B | THR273 |
B | HOH389 |
B | HOH411 |
B | HOH444 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL B 322 |
Chain | Residue |
A | LEU227 |
A | LEU231 |
B | VAL202 |
B | ILE203 |
B | HOH440 |
B | HOH562 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL B 323 |
Chain | Residue |
A | ASN199 |
A | LYS215 |
B | ASP171 |
B | PHE172 |
B | ALA173 |
B | HOH477 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL B 324 |
Chain | Residue |
B | TYR142 |
B | PHE144 |
B | HOH385 |
B | HOH591 |
site_id | BC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 325 |
Chain | Residue |
B | ARG239 |
B | THR311 |
B | HOH565 |
site_id | BC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 B 326 |
Chain | Residue |
B | ASN54 |
B | SER69 |
B | MET70 |
B | GLY71 |
B | HOH355 |
B | HOH358 |
B | HOH364 |
B | HOH367 |