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3TJV

Crystal structure of human granzyme H with a peptidyl substrate

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0008236molecular_functionserine-type peptidase activity
A0016020cellular_componentmembrane
A0031640biological_processkilling of cells of another organism
A0043231cellular_componentintracellular membrane-bounded organelle
A0044194cellular_componentcytolytic granule
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 276
ChainResidue
AARG50
ALYS51
ATRP115
AHOH264
AHOH268

site_idAC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SO4 A 277
ChainResidue
ALYS112

site_idAC3
Number of Residues22
DetailsBINDING SITE FOR CHAIN B OF PTSYAGDDSG
ChainResidue
AARG43
ACYS44
AHIS59
ALYS75
APHE100
AASN174
AGLY192
APHE193
ALYS194
AGLY195
AASP196
ASER197
ASER212
ATYR213
AGLY214
AASN215
ALYS216
AGLY218
BHOH266
AGLN34
AARG41
ALYS42

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
ALEU55-CYS60

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. TGfkGDSGGPLV
ChainResidueDetails
ATHR191-VAL202

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system => ECO:0000250
ChainResidueDetails
AHIS59
AASN103
ASER197

site_idSWS_FT_FI2
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN66
AASN99
AASN174

219140

PDB entries from 2024-05-01

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