Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3THO

Crystal structure of Mre11:Rad50 in its ATP/ADP bound state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006302	biological_process	double-strand break repair
A	0016887	molecular_function	ATP hydrolysis activity
B	0003677	molecular_function	DNA binding
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0004520	molecular_function	DNA endonuclease activity
B	0004527	molecular_function	exonuclease activity
B	0004529	molecular_function	DNA exonuclease activity
B	0005515	molecular_function	protein binding
B	0006259	biological_process	DNA metabolic process
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0006302	biological_process	double-strand break repair
B	0006310	biological_process	DNA recombination
B	0008408	molecular_function	3'-5' exonuclease activity
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE ADP A 1452

Chain	Residue
A	LEU12
A	SER38
A	ARG53
A	TYR54
A	ASP59
A	VAL61
A	ASN62
A	ARG63
A	ARG741
A	ARG762
A	GLY766
A	GLY13
A	SER768
A	GLU798
A	MG853
A	HOH864
A	HOH873
A	PRO31
A	ASN32
A	GLY33
A	ALA34
A	GLY35
A	LYS36
A	SER37

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 853

Chain	Residue
A	SER37
A	SER768
A	GLY769
A	GLU798
A	HOH876
A	ADP1452

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 854

Chain	Residue
A	SER57
A	HIS96

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 855

Chain	Residue
A	ARG71
A	ILE86
A	LYS99

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 856

Chain	Residue
A	ALA113
A	ALA114
A	SER118

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 857

Chain	Residue
A	PHE21
A	GLN22
A	GLY24
A	ILE25
A	THR26
A	VAL824
A	ILE825
A	VAL826
A	ARG840

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 858

Chain	Residue
A	SER166
A	ARG790

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 859

Chain	Residue
A	GLU798
A	SER801
A	THR829
A	CYS830

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 1

Chain	Residue
B	ASP14
B	HIS16
B	ASP58
B	GLN94
B	HIS216
B	HIS218

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN B 2

Chain	Residue
B	ASP58
B	ASN93
B	HIS180
B	HIS216

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 386

Chain	Residue
B	SO44
B	MET7
B	GLN130
B	LYS255
B	HOH393

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 4

Chain	Residue
B	ARG128
B	GLU253
B	LYS255
B	SO4386

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 5

Chain	Residue
B	TRP22
B	THR23
B	SER24
B	LYS322

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 387

Chain	Residue
A	ARG63
A	ILE760
A	GLU761
B	GLU166
B	LEU169
B	LYS170

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGERALISISLAM

Chain	Residue	Details
A	LEU767-MET781

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25349191","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25349191","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25349191","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"4W9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q8U1N9","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_02044","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24316220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3THN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O24","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O43","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O5G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24316220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3THN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O24","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O4K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24316220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NZV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)