3TC7
Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0004425 | molecular_function | indole-3-glycerol-phosphate synthase activity |
| A | 0006568 | biological_process | L-tryptophan metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 301 |
| Chain | Residue |
| A | ARG3 |
| A | TYR4 |
| A | ARG97 |
| A | HOH603 |
| A | HOH629 |
| A | HOH743 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 302 |
| Chain | Residue |
| A | ARG238 |
| A | ASN239 |
| A | LYS242 |
| A | HOH700 |
| A | ASN164 |
| A | ARG171 |
| A | SER235 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PO4 A 303 |
| Chain | Residue |
| A | GLU51 |
| A | LYS53 |
| A | LYS210 |
| A | GLU211 |
| A | ILE232 |
| A | GLY233 |
| A | SER234 |
| A | HOH635 |
| A | HOH646 |
| A | HOH654 |
| A | HOH748 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACY A 401 |
| Chain | Residue |
| A | ASN44 |
| A | THR46 |
| A | GLU220 |
| A | ARG223 |
| A | HOH633 |
| A | HOH711 |
| A | HOH765 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 252 |
| Chain | Residue | Details |
| A | GLU51 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity, proton acceptor, proton donor |
| A | LYS53 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor |
| A | TYR110 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ILE159 | activator, hydrogen bond acceptor, increase nucleophilicity |
| A | ALA180 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase acidity |
| A | LYS210 | electrostatic stabiliser |
| A | GLU211 | electrostatic stabiliser, hydrogen bond donor |
