3TC6
Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR63.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | tryptophan biosynthetic process |
| A | 0004425 | molecular_function | indole-3-glycerol-phosphate synthase activity |
| A | 0004640 | molecular_function | phosphoribosylanthranilate isomerase activity |
| A | 0006568 | biological_process | tryptophan metabolic process |
| A | 0016830 | molecular_function | carbon-carbon lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 A 301 |
| Chain | Residue |
| A | ARG97 |
| A | ASN164 |
| A | ARG171 |
| A | SER235 |
| A | ARG238 |
| A | ASN239 |
| A | LYS242 |
| A | HOH649 |
| A | HOH689 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A 302 |
| Chain | Residue |
| A | LYS53 |
| A | ARG182 |
| A | ALA211 |
| A | GLY233 |
| A | SER234 |
| A | HOH524 |
| A | HOH573 |
| A | HOH625 |
| A | HOH634 |
| A | HOH658 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 303 |
| Chain | Residue |
| A | ARG36 |
| A | GLU39 |
| A | LYS42 |
| A | ARG43 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 304 |
| Chain | Residue |
| A | SER25 |
| A | GLN27 |
| A | ASP162 |
| A | GLU163 |
| A | ASN193 |
| A | LYS196 |
| A | HOH660 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG A 401 |
| Chain | Residue |
| A | TRP8 |
| A | GLU185 |
| A | THR186 |
| A | LEU187 |
| A | ASN204 |
| A | HOH563 |
| A | HOH675 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG A 402 |
| Chain | Residue |
| A | ILE201 |
Functional Information from PROSITE/UniProt
| site_id | PS00614 |
| Number of Residues | 15 |
| Details | IGPS Indole-3-glycerol phosphate synthase signature. IIaEYKRKSPSgld....V |
| Chain | Residue | Details |
| A | ILE48-VAL62 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 252 |
| Chain | Residue | Details |
| A | GLU51 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity, proton acceptor, proton donor |
| A | LYS53 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor |
| A | SER110 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | VAL159 | activator, hydrogen bond acceptor, increase nucleophilicity |
| A | GLU180 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase acidity |
| A | ILE210 | electrostatic stabiliser |
| A | ALA211 | electrostatic stabiliser, hydrogen bond donor |
