Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3TBT

CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P, Y4S)

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0006968	biological_process	cellular defense response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0010977	biological_process	negative regulation of neuron projection development
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031902	cellular_component	late endosome membrane
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
E	0001913	biological_process	T cell mediated cytotoxicity
E	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
E	0002237	biological_process	response to molecule of bacterial origin
E	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
E	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
E	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
E	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
E	0002726	biological_process	positive regulation of T cell cytokine production
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005765	cellular_component	lysosomal membrane
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0006968	biological_process	cellular defense response
E	0007608	biological_process	sensory perception of smell
E	0007611	biological_process	learning or memory
E	0009897	cellular_component	external side of plasma membrane
E	0010977	biological_process	negative regulation of neuron projection development
E	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
E	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
E	0023026	molecular_function	MHC class II protein complex binding
E	0030670	cellular_component	phagocytic vesicle membrane
E	0031902	cellular_component	late endosome membrane
E	0033077	biological_process	T cell differentiation in thymus
E	0034756	biological_process	regulation of iron ion transport
E	0042026	biological_process	protein refolding
E	0042605	molecular_function	peptide antigen binding
E	0042612	cellular_component	MHC class I protein complex
E	0042613	cellular_component	MHC class II protein complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042824	cellular_component	MHC class I peptide loading complex
E	0045646	biological_process	regulation of erythrocyte differentiation
E	0048260	biological_process	positive regulation of receptor-mediated endocytosis
E	0050680	biological_process	negative regulation of epithelial cell proliferation
E	0050768	biological_process	negative regulation of neurogenesis
E	0050778	biological_process	positive regulation of immune response
E	0050870	biological_process	positive regulation of T cell activation
E	0051289	biological_process	protein homotetramerization
E	0060586	biological_process	multicellular organismal-level iron ion homeostasis
E	0071281	biological_process	cellular response to iron ion
E	0071283	biological_process	cellular response to iron(III) ion
E	0071316	biological_process	cellular response to nicotine
E	1990000	biological_process	amyloid fibril formation
E	1990712	cellular_component	HFE-transferrin receptor complex
E	2000774	biological_process	positive regulation of cellular senescence
E	2000978	biological_process	negative regulation of forebrain neuron differentiation
H	0001913	biological_process	T cell mediated cytotoxicity
H	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
H	0002237	biological_process	response to molecule of bacterial origin
H	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
H	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
H	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
H	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
H	0002726	biological_process	positive regulation of T cell cytokine production
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005765	cellular_component	lysosomal membrane
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0006968	biological_process	cellular defense response
H	0007608	biological_process	sensory perception of smell
H	0007611	biological_process	learning or memory
H	0009897	cellular_component	external side of plasma membrane
H	0010977	biological_process	negative regulation of neuron projection development
H	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
H	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
H	0023026	molecular_function	MHC class II protein complex binding
H	0030670	cellular_component	phagocytic vesicle membrane
H	0031902	cellular_component	late endosome membrane
H	0033077	biological_process	T cell differentiation in thymus
H	0034756	biological_process	regulation of iron ion transport
H	0042026	biological_process	protein refolding
H	0042605	molecular_function	peptide antigen binding
H	0042612	cellular_component	MHC class I protein complex
H	0042613	cellular_component	MHC class II protein complex
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042824	cellular_component	MHC class I peptide loading complex
H	0045646	biological_process	regulation of erythrocyte differentiation
H	0048260	biological_process	positive regulation of receptor-mediated endocytosis
H	0050680	biological_process	negative regulation of epithelial cell proliferation
H	0050768	biological_process	negative regulation of neurogenesis
H	0050778	biological_process	positive regulation of immune response
H	0050870	biological_process	positive regulation of T cell activation
H	0051289	biological_process	protein homotetramerization
H	0060586	biological_process	multicellular organismal-level iron ion homeostasis
H	0071281	biological_process	cellular response to iron ion
H	0071283	biological_process	cellular response to iron(III) ion
H	0071316	biological_process	cellular response to nicotine
H	1990000	biological_process	amyloid fibril formation
H	1990712	cellular_component	HFE-transferrin receptor complex
H	2000774	biological_process	positive regulation of cellular senescence
H	2000978	biological_process	negative regulation of forebrain neuron differentiation
K	0001913	biological_process	T cell mediated cytotoxicity
K	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
K	0002237	biological_process	response to molecule of bacterial origin
K	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
K	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
K	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
K	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
K	0002726	biological_process	positive regulation of T cell cytokine production
K	0005198	molecular_function	structural molecule activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005765	cellular_component	lysosomal membrane
K	0005794	cellular_component	Golgi apparatus
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006955	biological_process	immune response
K	0006968	biological_process	cellular defense response
K	0007608	biological_process	sensory perception of smell
K	0007611	biological_process	learning or memory
K	0009897	cellular_component	external side of plasma membrane
K	0010977	biological_process	negative regulation of neuron projection development
K	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
K	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
K	0023026	molecular_function	MHC class II protein complex binding
K	0030670	cellular_component	phagocytic vesicle membrane
K	0031902	cellular_component	late endosome membrane
K	0033077	biological_process	T cell differentiation in thymus
K	0034756	biological_process	regulation of iron ion transport
K	0042026	biological_process	protein refolding
K	0042605	molecular_function	peptide antigen binding
K	0042612	cellular_component	MHC class I protein complex
K	0042613	cellular_component	MHC class II protein complex
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0042824	cellular_component	MHC class I peptide loading complex
K	0045646	biological_process	regulation of erythrocyte differentiation
K	0048260	biological_process	positive regulation of receptor-mediated endocytosis
K	0050680	biological_process	negative regulation of epithelial cell proliferation
K	0050768	biological_process	negative regulation of neurogenesis
K	0050778	biological_process	positive regulation of immune response
K	0050870	biological_process	positive regulation of T cell activation
K	0051289	biological_process	protein homotetramerization
K	0060586	biological_process	multicellular organismal-level iron ion homeostasis
K	0071281	biological_process	cellular response to iron ion
K	0071283	biological_process	cellular response to iron(III) ion
K	0071316	biological_process	cellular response to nicotine
K	1990000	biological_process	amyloid fibril formation
K	1990712	cellular_component	HFE-transferrin receptor complex
K	2000774	biological_process	positive regulation of cellular senescence
K	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	29
Details	BINDING SITE FOR CHAIN C OF GLYCOPROTEIN G1

Chain	Residue
A	TYR7
A	TYR84
A	GLN97
A	SER99
A	PHE116
A	THR143
A	LYS146
A	TRP147
A	SER150
A	HIS155
A	TYR156
A	GLU9
A	TYR159
A	GLU163
A	TRP167
A	TYR171
A	HOH995
C	HOH748
C	HOH964
C	HOH1123
C	HOH1167
C	HOH1181
A	TYR45
A	ARG62
A	GLU63
A	LYS66
A	GLN70
A	TRP73
A	SER77

site_id	AC2
Number of Residues	26
Details	BINDING SITE FOR CHAIN F OF GLYCOPROTEIN G1

Chain	Residue
D	TYR7
D	GLU9
D	ARG62
D	GLU63
D	LYS66
D	GLN70
D	TRP73
D	SER77
D	ASN80
D	LEU81
D	TYR84
D	LEU95
D	GLN97
D	SER99
D	PHE116
D	THR143
D	LYS146
D	TRP147
D	HIS155
D	TYR156
D	TYR159
D	TYR171
D	HOH341
D	HOH1053
F	HOH1005
F	HOH1368

site_id	AC3
Number of Residues	26
Details	BINDING SITE FOR CHAIN I OF GLYCOPROTEIN G1

Chain	Residue
G	MET5
G	TYR7
G	GLU9
G	TYR45
G	GLU63
G	LYS66
G	GLN70
G	TRP73
G	SER77
G	ASN80
G	TYR84
G	GLN97
G	SER99
G	PHE116
G	THR143
G	TRP147
G	HIS155
G	TYR156
G	TYR159
G	GLU163
G	TRP167
G	TYR171
G	HOH1099
G	HOH1163
I	HOH10
I	HOH910

site_id	AC4
Number of Residues	30
Details	BINDING SITE FOR CHAIN L OF GLYCOPROTEIN G1

Chain	Residue
J	HIS155
J	TYR156
J	TYR159
J	GLU163
J	TRP167
J	TYR171
J	HOH1188
L	HOH227
L	HOH975
L	HOH990
L	HOH1367
L	HOH1496
J	TYR7
J	GLU9
J	TYR45
J	ARG62
J	GLU63
J	LYS66
J	GLN70
J	TRP73
J	SER77
J	ASN80
J	TYR84
J	LEU95
J	GLN97
J	SER99
J	PHE116
J	THR143
J	LYS146
J	TRP147

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVKH

Chain	Residue	Details
B	TYR78-HIS84
A	TYR257-HIS263

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:3980466, ECO:0000269\|PubMed:7118212

Chain	Residue	Details
A	ASN86
D	ASN86
G	ASN86
J	ASN86

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305

Chain	Residue	Details
A	ASN176
D	ASN176
G	ASN176
J	ASN176

site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:3980466

Chain	Residue	Details
A	ASN256
D	ASN256
G	ASN256
J	ASN256

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)