Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| F | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| F | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU B 274 |
| Chain | Residue |
| B | TYR61 |
| B | TYR220 |
| B | HOH263 |
| B | HOH266 |
| B | HOH298 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | ARG96 |
| B | GLY141 |
| B | SER142 |
| B | THR143 |
| B | GLU193 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 1 |
| Chain | Residue |
| B | GLU42 |
| B | HIS46 |
| D | GLU166 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN B 3 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GLU D 274 |
| Chain | Residue |
| D | TYR61 |
| D | PRO89 |
| D | LEU90 |
| D | THR91 |
| D | ARG96 |
| D | GLY141 |
| D | SER142 |
| D | THR143 |
| D | GLU193 |
| D | HOH312 |
| D | HOH315 |
| D | HOH327 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN D 2 |
| Chain | Residue |
| B | GLU166 |
| D | GLU42 |
| D | HIS46 |
| D | LEU241 |
| D | GLN244 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN D 262 |
| Chain | Residue |
| D | LYS20 |
| D | HIS23 |
| D | GLU30 |
| F | HIS23 |
| F | GLU24 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU F 274 |
| Chain | Residue |
| F | TYR61 |
| F | PRO89 |
| F | LEU90 |
| F | THR91 |
| F | ARG96 |
| F | LEU138 |
| F | GLY141 |
| F | SER142 |
| F | THR143 |
| F | GLU193 |
| F | HOH265 |
| F | HOH278 |
| F | HOH321 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN F 262 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. GTLDSGSTKCFF |
| Chain | Residue | Details |
| B | GLY136-PHE147 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| B | TYR61 | |
| B | ARG96 | |
| B | GLU193 | |
| D | TYR61 | |
| D | ARG96 | |
| D | GLU193 | |
| F | TYR61 | |
| F | ARG96 | |
| F | GLU193 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | PRO89 | |
| D | PRO89 | |
| F | PRO89 | |
| Chain | Residue | Details |
| B | THR91 | |
| B | SER142 | |
| B | THR143 | |
| D | THR91 | |
| D | SER142 | |
| D | THR143 | |
| F | THR91 | |
| F | SER142 | |
| F | THR143 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| B | ARG64 | |
| B | ARG148 | |
| B | LYS240 | |
| D | ARG64 | |
| D | ARG148 | |
| D | LYS240 | |
| F | ARG64 | |
| F | ARG148 | |
| F | LYS240 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| B | ILE121 | |
| D | ILE121 | |
| F | ILE121 | |
| Chain | Residue | Details |
| B | SER150 | |
| D | SER150 | |
| F | SER150 | |
| Chain | Residue | Details |
| B | SER184 | |
| D | SER184 | |
| F | SER184 | |
