Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE UBZ A 317 |
| Chain | Residue |
| A | TYR106 |
| A | GLU166 |
| A | LEU202 |
| A | ARG203 |
| A | HIS231 |
| A | GOL319 |
| A | DMS321 |
| A | DMS321 |
| A | ZN326 |
| A | HOH621 |
| A | HOH633 |
| A | ASN112 |
| A | HOH683 |
| A | ALA113 |
| A | PHE114 |
| A | TRP115 |
| A | HIS142 |
| A | GLU143 |
| A | HIS146 |
| A | TYR157 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 318 |
| Chain | Residue |
| A | GLY109 |
| A | TYR110 |
| A | ASN111 |
| A | ASN112 |
| A | HOH674 |
| A | HOH713 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 319 |
| Chain | Residue |
| A | PHE114 |
| A | TRP115 |
| A | HIS146 |
| A | TYR157 |
| A | UBZ317 |
| A | HOH490 |
| A | HOH515 |
| A | HOH537 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL A 320 |
| Chain | Residue |
| A | GLY247 |
| A | GLY248 |
| A | THR249 |
| A | VAL255 |
| A | GLN273 |
| A | LEU275 |
| A | HOH535 |
| A | HOH573 |
| A | HOH588 |
| A | HOH635 |
| A | HOH658 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 321 |
| Chain | Residue |
| A | TYR110 |
| A | ASN112 |
| A | PHE114 |
| A | UBZ317 |
| A | UBZ317 |
| A | HOH793 |
| A | HOH802 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 322 |
| Chain | Residue |
| A | ILE1 |
| A | THR2 |
| A | GLY3 |
| A | GLN31 |
| A | ASN33 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 323 |
| Chain | Residue |
| A | TYR66 |
| A | HIS216 |
| A | SER218 |
| A | TYR251 |
| A | HOH351 |
| A | HOH412 |
| A | HOH647 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 324 |
| Chain | Residue |
| A | THR4 |
| A | TYR24 |
| A | TYR24 |
| A | SER25 |
| A | TYR28 |
| A | HOH717 |
| A | HOH722 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 325 |
| Chain | Residue |
| A | GLY95 |
| A | PRO184 |
| A | TRP186 |
| A | HOH570 |
| A | HOH732 |
| A | HOH739 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 326 |
| Chain | Residue |
| A | HIS142 |
| A | HIS146 |
| A | GLU166 |
| A | UBZ317 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 327 |
| Chain | Residue |
| A | ASP138 |
| A | GLU177 |
| A | ASP185 |
| A | GLU187 |
| A | GLU190 |
| A | HOH785 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 328 |
| Chain | Residue |
| A | GLU177 |
| A | ASN183 |
| A | ASP185 |
| A | GLU190 |
| A | HOH790 |
| A | HOH791 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 329 |
| Chain | Residue |
| A | TYR193 |
| A | THR194 |
| A | ILE197 |
| A | ASP200 |
| A | HOH788 |
| A | HOH792 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 330 |
| Chain | Residue |
| A | ASP57 |
| A | ASP59 |
| A | GLN61 |
| A | HOH786 |
| A | HOH787 |
| A | HOH789 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV |
| Chain | Residue | Details |
| A | VAL139-VAL148 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4808703","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4808703","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 176 |
| Chain | Residue | Details |
| A | HIS142 | metal ligand |
| A | GLU143 | electrostatic stabiliser, metal ligand |
| A | HIS146 | metal ligand |
| A | TYR157 | electrostatic stabiliser, hydrogen bond donor, steric role |
| A | GLU166 | metal ligand |
| A | ASP226 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | HIS231 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
