3T4N
Structure of the regulatory fragment of Saccharomyces cerevisiae AMPK in complex with ADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0004679 | molecular_function | AMP-activated protein kinase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005641 | cellular_component | nuclear envelope lumen |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| C | 0006914 | biological_process | autophagy |
| C | 0007031 | biological_process | peroxisome organization |
| C | 0016208 | molecular_function | AMP binding |
| C | 0019887 | molecular_function | protein kinase regulator activity |
| C | 0019901 | molecular_function | protein kinase binding |
| C | 0030447 | biological_process | filamentous growth |
| C | 0031588 | cellular_component | nucleotide-activated protein kinase complex |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043539 | molecular_function | protein serine/threonine kinase activator activity |
| C | 0045722 | biological_process | positive regulation of gluconeogenesis |
| C | 1904547 | biological_process | regulation of cellular response to glucose starvation |
| C | 2000217 | biological_process | regulation of invasive growth in response to glucose limitation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP C 324 |
| Chain | Residue |
| C | GLN168 |
| C | THR310 |
| C | SER312 |
| C | ASP313 |
| C | HOH394 |
| C | HOH397 |
| C | HOH406 |
| C | HOH417 |
| C | THR196 |
| C | ASN199 |
| C | MET200 |
| C | LYS201 |
| C | VAL221 |
| C | SER222 |
| C | SER223 |
| C | PRO225 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q10343 |
| Chain | Residue | Details |
| C | ILE43 | |
| C | ARG147 | |
| C | THR167 | |
| C | ARG292 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22019086, ECO:0007744|PDB:3T4N |
| Chain | Residue | Details |
| C | THR196 | |
| C | LYS201 | |
| C | SER222 | |
| C | THR310 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| A | LYS461 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:24108357 |
| Chain | Residue | Details |
| A | LYS549 |
