3T4E
1.95 Angstrom Crystal Structure of Shikimate 5-dehydrogenase (AroE) from Salmonella enterica subsp. enterica serovar Typhimurium in Complex with NAD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004764 | molecular_function | shikimate 3-dehydrogenase (NADP+) activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019632 | biological_process | shikimate metabolic process |
| A | 0030266 | molecular_function | quinate 3-dehydrogenase (NAD+) activity |
| A | 0052733 | molecular_function | quinate 3-dehydrogenase (NADP+) activity |
| A | 0052734 | molecular_function | shikimate 3-dehydrogenase (NAD+) activity |
| B | 0004764 | molecular_function | shikimate 3-dehydrogenase (NADP+) activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019632 | biological_process | shikimate metabolic process |
| B | 0030266 | molecular_function | quinate 3-dehydrogenase (NAD+) activity |
| B | 0052733 | molecular_function | quinate 3-dehydrogenase (NADP+) activity |
| B | 0052734 | molecular_function | shikimate 3-dehydrogenase (NAD+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NAD A 289 |
| Chain | Residue |
| A | GLY131 |
| A | GLY203 |
| A | THR204 |
| A | LYS205 |
| A | VAL206 |
| A | MET208 |
| A | LEU211 |
| A | CYS232 |
| A | VAL233 |
| A | TYR234 |
| A | GLY255 |
| A | ALA132 |
| A | MET258 |
| A | LEU259 |
| A | PO4290 |
| A | HOH301 |
| A | HOH304 |
| A | HOH313 |
| A | HOH327 |
| A | HOH456 |
| A | HOH492 |
| A | HOH496 |
| A | GLY133 |
| A | HOH510 |
| A | HOH512 |
| A | HOH602 |
| A | GLY134 |
| A | ALA135 |
| A | ASN155 |
| A | ARG156 |
| A | ASP158 |
| A | PHE160 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A 290 |
| Chain | Residue |
| A | SER67 |
| A | LYS71 |
| A | ASN92 |
| A | ASP107 |
| A | NAD289 |
| A | HOH346 |
| A | HOH375 |
| A | HOH421 |
| A | HOH429 |
| A | HOH492 |
| site_id | AC3 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD B 289 |
| Chain | Residue |
| B | GLY131 |
| B | ALA132 |
| B | GLY133 |
| B | GLY134 |
| B | ALA135 |
| B | ASN155 |
| B | ARG156 |
| B | ASP158 |
| B | PHE160 |
| B | GLY203 |
| B | THR204 |
| B | LYS205 |
| B | VAL206 |
| B | MET208 |
| B | LEU211 |
| B | CYS232 |
| B | TYR234 |
| B | GLY255 |
| B | MET258 |
| B | LEU259 |
| B | PO4290 |
| B | HOH293 |
| B | HOH315 |
| B | HOH333 |
| B | HOH355 |
| B | HOH428 |
| B | HOH448 |
| B | HOH452 |
| B | HOH453 |
| B | HOH536 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 B 290 |
| Chain | Residue |
| B | SER67 |
| B | LYS71 |
| B | ASN92 |
| B | ASP107 |
| B | NAD289 |
| B | HOH325 |
| B | HOH351 |
| B | HOH472 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01578","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01578","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2011","submissionDatabase":"PDB data bank","title":"1.95 angstrom crystal structure of shikimate 5-dehydrogenase (AroE) from Salmonella enterica subsp. enterica serovar Typhimurium in complex with NAD.","authors":["Minasov G.","Light S.H.","Halavaty A.","Shuvalova L.","Dubrovska I.","Winsor J.","Papazisi L.","Anderson W.F."]}}]} |
| Chain | Residue | Details |
