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3T2G

Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, Y229F variant with DHAP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004332molecular_functionfructose-bisphosphate aldolase activity
A0006094biological_processgluconeogenesis
A0016787molecular_functionhydrolase activity
A0016829molecular_functionlyase activity
A0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 408
ChainResidue
AASP11
AASP52
AASP53
AASP132
AASP234
A13P410

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 409
ChainResidue
AGLN95
A13P410
AASP11
AHIS18
AASP52

site_idAC3
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 13P A 410
ChainResidue
AASP11
AHIS18
AASP52
AGLN95
AASP132
ALYS133
AASP233
AASP234
AMET265
AARG266
AGLY267
AASP297
AMG408
AMG409
A13P411

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 13P A 411
ChainResidue
AHIS18
ATYR91
AGLN242
ASER243
AALA247
AASP297
A13P410

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor; for FBP phosphatase activity => ECO:0000250|UniProtKB:F9VMT6
ChainResidueDetails
AASP11

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Proton donor/acceptor; for FBP aldolase activity => ECO:0000305|PubMed:21983965
ChainResidueDetails
APHE229

site_idSWS_FT_FI3
Number of Residues1
DetailsACT_SITE: Schiff-base intermediate with DHAP; for FBP aldolase activity => ECO:0000269|PubMed:21983965
ChainResidueDetails
ALYS232

site_idSWS_FT_FI4
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:21983965, ECO:0007744|PDB:3T2B, ECO:0007744|PDB:3T2C, ECO:0007744|PDB:3T2D
ChainResidueDetails
AHIS18
AASP52
AASP53
AASP132
AASP11

site_idSWS_FT_FI5
Number of Residues3
DetailsBINDING: in other chain => ECO:0000269|PubMed:21983965, ECO:0007744|PDB:3T2D
ChainResidueDetails
AGLY104
ATYR358
ATYR91

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:21983965, ECO:0007744|PDB:3T2C, ECO:0007744|PDB:3T2D, ECO:0007744|PDB:3T2E
ChainResidueDetails
AGLN95

site_idSWS_FT_FI7
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:21983965, ECO:0007744|PDB:3T2C
ChainResidueDetails
AARG266
AASP297
ALYS133

site_idSWS_FT_FI8
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:F9VMT6
ChainResidueDetails
ALYS232

site_idSWS_FT_FI9
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:21983965
ChainResidueDetails
AASP233
AASP234
AGLN242

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PDB entries from 2024-05-01

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