3T2E
Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, F6P-bound form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0042132 | molecular_function | fructose 1,6-bisphosphate 1-phosphatase activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 408 |
| Chain | Residue |
| A | ASP52 |
| A | ASP53 |
| A | ASP132 |
| A | ASP234 |
| A | HOH418 |
| A | HOH419 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 409 |
| Chain | Residue |
| A | GLN95 |
| A | HOH416 |
| A | HOH417 |
| A | ASP11 |
| A | HIS18 |
| A | ASP52 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE F6R A 3469 |
| Chain | Residue |
| A | HIS18 |
| A | TYR91 |
| A | GLN242 |
| A | SER243 |
| A | ALA247 |
| A | TRP264 |
| A | MET265 |
| A | ARG266 |
| A | GLY267 |
| A | ASP297 |
| A | TYR358 |
| A | HOH410 |
| A | HOH413 |
| A | HOH414 |
| A | HOH415 |
| A | HOH423 |
| A | HOH424 |
| A | HOH426 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor; for FBP phosphatase activity","evidences":[{"source":"UniProtKB","id":"F9VMT6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor; for FBP aldolase activity","evidences":[{"source":"PubMed","id":"21983965","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Schiff-base intermediate with DHAP; for FBP aldolase activity","evidences":[{"source":"PubMed","id":"21983965","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21983965","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T2B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T2D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"21983965","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T2D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21983965","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T2E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21983965","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T2C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"F9VMT6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21983965","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
