3T2E
Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, F6P-bound form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0042132 | molecular_function | fructose 1,6-bisphosphate 1-phosphatase activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 408 |
| Chain | Residue |
| A | ASP52 |
| A | ASP53 |
| A | ASP132 |
| A | ASP234 |
| A | HOH418 |
| A | HOH419 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 409 |
| Chain | Residue |
| A | GLN95 |
| A | HOH416 |
| A | HOH417 |
| A | ASP11 |
| A | HIS18 |
| A | ASP52 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE F6R A 3469 |
| Chain | Residue |
| A | HIS18 |
| A | TYR91 |
| A | GLN242 |
| A | SER243 |
| A | ALA247 |
| A | TRP264 |
| A | MET265 |
| A | ARG266 |
| A | GLY267 |
| A | ASP297 |
| A | TYR358 |
| A | HOH410 |
| A | HOH413 |
| A | HOH414 |
| A | HOH415 |
| A | HOH423 |
| A | HOH424 |
| A | HOH426 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor; for FBP phosphatase activity => ECO:0000250|UniProtKB:F9VMT6 |
| Chain | Residue | Details |
| A | ASP11 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor; for FBP aldolase activity => ECO:0000305|PubMed:21983965 |
| Chain | Residue | Details |
| A | TYR229 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: Schiff-base intermediate with DHAP; for FBP aldolase activity => ECO:0000269|PubMed:21983965 |
| Chain | Residue | Details |
| A | LYS232 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21983965, ECO:0007744|PDB:3T2B, ECO:0007744|PDB:3T2C, ECO:0007744|PDB:3T2D |
| Chain | Residue | Details |
| A | ASP11 | |
| A | HIS18 | |
| A | ASP52 | |
| A | ASP53 | |
| A | ASP132 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | BINDING: in other chain => ECO:0000269|PubMed:21983965, ECO:0007744|PDB:3T2D |
| Chain | Residue | Details |
| A | TYR91 | |
| A | GLY104 | |
| A | TYR358 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21983965, ECO:0007744|PDB:3T2C, ECO:0007744|PDB:3T2D, ECO:0007744|PDB:3T2E |
| Chain | Residue | Details |
| A | GLN95 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21983965, ECO:0007744|PDB:3T2C |
| Chain | Residue | Details |
| A | LYS133 | |
| A | ARG266 | |
| A | ASP297 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:F9VMT6 |
| Chain | Residue | Details |
| A | LYS232 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21983965 |
| Chain | Residue | Details |
| A | ASP233 | |
| A | ASP234 | |
| A | GLN242 |
