3T2C

Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, DHAP-bound form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004332	molecular_function	fructose-bisphosphate aldolase activity
A	0006094	biological_process	gluconeogenesis
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 408

Chain	Residue
A	LYS232
A	ASP234
A	MG409
A	13P411
A	HOH414
A	HOH415
A	HOH416

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MG A 409

Chain	Residue
A	ASP132
A	LYS133
A	ASP234
A	MG408
A	13P411
A	HOH414
A	ASP52
A	ASP53

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 410

Chain	Residue
A	ASP11
A	HIS18
A	ASP52
A	GLN95
A	13P411
A	HOH413

---

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE 13P A 411

Chain	Residue
A	ASP11
A	HIS18
A	ASP52
A	GLN95
A	ASP132
A	LYS133
A	TYR229
A	GLY231
A	LYS232
A	ASP234
A	TRP264
A	MET265
A	ARG266
A	GLY267
A	ASP297
A	MG408
A	MG409
A	MG410
A	13P412
A	HOH414
A	HOH416
A	HOH736
A	HOH738

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 13P A 412

Chain	Residue
A	HIS18
A	TYR91
A	TYR229
A	LYS232
A	GLN242
A	SER243
A	ALA247
A	ARG266
A	ASP297
A	TYR358
A	13P411
A	HOH462
A	HOH576
A	HOH657

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor; for FBP phosphatase activity","evidences":[{"source":"UniProtKB","id":"F9VMT6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor; for FBP aldolase activity","evidences":[{"source":"PubMed","id":"21983965","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Schiff-base intermediate with DHAP; for FBP aldolase activity","evidences":[{"source":"PubMed","id":"21983965","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21983965","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T2B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T2D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"21983965","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T2D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21983965","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T2E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21983965","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T2C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"F9VMT6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21983965","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---