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3T14

Crystal structure of sulfide:quinone oxidoreductase Cys128Ala variant from Acidithiobacillus ferrooxidans with bound disulfide

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0048038molecular_functionquinone binding
A0070224molecular_functionsulfide:quinone oxidoreductase activity
Functional Information from PDB Data
site_idAC1
Number of Residues37
DetailsBINDING SITE FOR RESIDUE FAD A 500
ChainResidue
ALEU7
ASER77
AALA78
AALA104
ATHR105
AGLY106
APRO107
AILE127
ACYS160
APRO163
AGLY301
AGLY8
AILE302
ALYS320
ATHR321
AGLY322
AILE325
AVAL355
ACYS356
APHE357
ALYS391
AHOH508
AALA9
AHOH516
AHOH561
AHOH565
AHOH599
AHOH612
AHOH649
AHOH681
AHOH683
AGLY10
ATHR11
AGLY12
ASER34
AALA35
AVAL42

site_idAC2
Number of Residues17
DetailsBINDING SITE FOR RESIDUE LMT A 501
ChainResidue
AMET169
AGLY205
AASP206
AILE210
AGLU217
ACYS356
AALA358
AALA365
APHE367
ATYR383
AHOH528
AHOH557
AHOH607
AHOH613
AHOH625
AHOH628
AHOH637

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 502
ChainResidue
AMET-2
AHIS3
AHIS97
AHOH588

site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE H2S A 504
ChainResidue
ACYS160
AS2H505

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE S2H A 505
ChainResidue
AGLY162
ACYS356
AH2S504

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 506
ChainResidue
AHIS334
AARG343
ALYS344
AGLY345
AGLU346

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 507
ChainResidue
AARG63
APHE73
AILE74
AALA75

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Cysteine persulfide intermediate => ECO:0000269|PubMed:20303979, ECO:0000269|PubMed:22542586
ChainResidueDetails
ACYS160
ACYS356

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:20303979, ECO:0000269|PubMed:22542586
ChainResidueDetails
AGLY8
ASER34
ASER77
AILE302
AGLY322
ALYS391

226707

PDB entries from 2024-10-30

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