Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3SWN

Structure of the LSm657 Complex: An Assembly Intermediate of the LSm1 7 and LSm2 8 Rings

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0005686	cellular_component	U2 snRNP
A	0005688	cellular_component	U6 snRNP
A	0005697	cellular_component	telomerase holoenzyme complex
A	0005730	cellular_component	nucleolus
A	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
A	0006364	biological_process	rRNA processing
A	0006397	biological_process	mRNA processing
A	0008033	biological_process	tRNA processing
A	0008266	molecular_function	poly(U) RNA binding
A	0008380	biological_process	RNA splicing
A	0022613	biological_process	ribonucleoprotein complex biogenesis
A	0030620	molecular_function	U2 snRNA binding
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0120115	cellular_component	Lsm2-8 complex
A	1905323	biological_process	telomerase holoenzyme complex assembly
A	1990726	cellular_component	Lsm1-7-Pat1 complex
A	1990904	cellular_component	ribonucleoprotein complex
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0000932	cellular_component	P-body
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005681	cellular_component	spliceosomal complex
B	0005682	cellular_component	U5 snRNP
B	0005686	cellular_component	U2 snRNP
B	0005688	cellular_component	U6 snRNP
B	0005697	cellular_component	telomerase holoenzyme complex
B	0005730	cellular_component	nucleolus
B	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
B	0005737	cellular_component	cytoplasm
B	0006364	biological_process	rRNA processing
B	0006397	biological_process	mRNA processing
B	0008033	biological_process	tRNA processing
B	0008266	molecular_function	poly(U) RNA binding
B	0008380	biological_process	RNA splicing
B	0030490	biological_process	maturation of SSU-rRNA
B	0030620	molecular_function	U2 snRNA binding
B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
B	0120114	cellular_component	Sm-like protein family complex
B	0120115	cellular_component	Lsm2-8 complex
B	1905323	biological_process	telomerase holoenzyme complex assembly
B	1990726	cellular_component	Lsm1-7-Pat1 complex
B	1990904	cellular_component	ribonucleoprotein complex
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0000956	biological_process	nuclear-transcribed mRNA catabolic process
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005681	cellular_component	spliceosomal complex
C	0005682	cellular_component	U5 snRNP
C	0005686	cellular_component	U2 snRNP
C	0005688	cellular_component	U6 snRNP
C	0005697	cellular_component	telomerase holoenzyme complex
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006364	biological_process	rRNA processing
C	0006397	biological_process	mRNA processing
C	0008033	biological_process	tRNA processing
C	0008266	molecular_function	poly(U) RNA binding
C	0008380	biological_process	RNA splicing
C	0030620	molecular_function	U2 snRNA binding
C	0045292	biological_process	mRNA cis splicing, via spliceosome
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0071004	cellular_component	U2-type prespliceosome
C	0071013	cellular_component	catalytic step 2 spliceosome
C	0097526	cellular_component	spliceosomal tri-snRNP complex
C	0120114	cellular_component	Sm-like protein family complex
C	0120115	cellular_component	Lsm2-8 complex
C	1905323	biological_process	telomerase holoenzyme complex assembly
C	1990726	cellular_component	Lsm1-7-Pat1 complex
C	1990904	cellular_component	ribonucleoprotein complex
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005681	cellular_component	spliceosomal complex
D	0005682	cellular_component	U5 snRNP
D	0005686	cellular_component	U2 snRNP
D	0005688	cellular_component	U6 snRNP
D	0005697	cellular_component	telomerase holoenzyme complex
D	0005730	cellular_component	nucleolus
D	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
D	0006364	biological_process	rRNA processing
D	0006397	biological_process	mRNA processing
D	0008033	biological_process	tRNA processing
D	0008266	molecular_function	poly(U) RNA binding
D	0008380	biological_process	RNA splicing
D	0022613	biological_process	ribonucleoprotein complex biogenesis
D	0030620	molecular_function	U2 snRNA binding
D	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
D	0120115	cellular_component	Lsm2-8 complex
D	1905323	biological_process	telomerase holoenzyme complex assembly
D	1990726	cellular_component	Lsm1-7-Pat1 complex
D	1990904	cellular_component	ribonucleoprotein complex
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0000932	cellular_component	P-body
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005681	cellular_component	spliceosomal complex
E	0005682	cellular_component	U5 snRNP
E	0005686	cellular_component	U2 snRNP
E	0005688	cellular_component	U6 snRNP
E	0005697	cellular_component	telomerase holoenzyme complex
E	0005730	cellular_component	nucleolus
E	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
E	0005737	cellular_component	cytoplasm
E	0006364	biological_process	rRNA processing
E	0006397	biological_process	mRNA processing
E	0008033	biological_process	tRNA processing
E	0008266	molecular_function	poly(U) RNA binding
E	0008380	biological_process	RNA splicing
E	0030490	biological_process	maturation of SSU-rRNA
E	0030620	molecular_function	U2 snRNA binding
E	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
E	0120114	cellular_component	Sm-like protein family complex
E	0120115	cellular_component	Lsm2-8 complex
E	1905323	biological_process	telomerase holoenzyme complex assembly
E	1990726	cellular_component	Lsm1-7-Pat1 complex
E	1990904	cellular_component	ribonucleoprotein complex
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0000956	biological_process	nuclear-transcribed mRNA catabolic process
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005681	cellular_component	spliceosomal complex
F	0005682	cellular_component	U5 snRNP
F	0005686	cellular_component	U2 snRNP
F	0005688	cellular_component	U6 snRNP
F	0005697	cellular_component	telomerase holoenzyme complex
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006364	biological_process	rRNA processing
F	0006397	biological_process	mRNA processing
F	0008033	biological_process	tRNA processing
F	0008266	molecular_function	poly(U) RNA binding
F	0008380	biological_process	RNA splicing
F	0030620	molecular_function	U2 snRNA binding
F	0045292	biological_process	mRNA cis splicing, via spliceosome
F	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
F	0071004	cellular_component	U2-type prespliceosome
F	0071013	cellular_component	catalytic step 2 spliceosome
F	0097526	cellular_component	spliceosomal tri-snRNP complex
F	0120114	cellular_component	Sm-like protein family complex
F	0120115	cellular_component	Lsm2-8 complex
F	1905323	biological_process	telomerase holoenzyme complex assembly
F	1990726	cellular_component	Lsm1-7-Pat1 complex
F	1990904	cellular_component	ribonucleoprotein complex
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0000956	biological_process	nuclear-transcribed mRNA catabolic process
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005681	cellular_component	spliceosomal complex
O	0005682	cellular_component	U5 snRNP
O	0005686	cellular_component	U2 snRNP
O	0005688	cellular_component	U6 snRNP
O	0005697	cellular_component	telomerase holoenzyme complex
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006364	biological_process	rRNA processing
O	0006397	biological_process	mRNA processing
O	0008033	biological_process	tRNA processing
O	0008266	molecular_function	poly(U) RNA binding
O	0008380	biological_process	RNA splicing
O	0030620	molecular_function	U2 snRNA binding
O	0045292	biological_process	mRNA cis splicing, via spliceosome
O	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
O	0071004	cellular_component	U2-type prespliceosome
O	0071013	cellular_component	catalytic step 2 spliceosome
O	0097526	cellular_component	spliceosomal tri-snRNP complex
O	0120114	cellular_component	Sm-like protein family complex
O	0120115	cellular_component	Lsm2-8 complex
O	1905323	biological_process	telomerase holoenzyme complex assembly
O	1990726	cellular_component	Lsm1-7-Pat1 complex
O	1990904	cellular_component	ribonucleoprotein complex
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005681	cellular_component	spliceosomal complex
P	0005682	cellular_component	U5 snRNP
P	0005686	cellular_component	U2 snRNP
P	0005688	cellular_component	U6 snRNP
P	0005697	cellular_component	telomerase holoenzyme complex
P	0005730	cellular_component	nucleolus
P	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
P	0006364	biological_process	rRNA processing
P	0006397	biological_process	mRNA processing
P	0008033	biological_process	tRNA processing
P	0008266	molecular_function	poly(U) RNA binding
P	0008380	biological_process	RNA splicing
P	0022613	biological_process	ribonucleoprotein complex biogenesis
P	0030620	molecular_function	U2 snRNA binding
P	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
P	0120115	cellular_component	Lsm2-8 complex
P	1905323	biological_process	telomerase holoenzyme complex assembly
P	1990726	cellular_component	Lsm1-7-Pat1 complex
P	1990904	cellular_component	ribonucleoprotein complex
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0000932	cellular_component	P-body
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005681	cellular_component	spliceosomal complex
Q	0005682	cellular_component	U5 snRNP
Q	0005686	cellular_component	U2 snRNP
Q	0005688	cellular_component	U6 snRNP
Q	0005697	cellular_component	telomerase holoenzyme complex
Q	0005730	cellular_component	nucleolus
Q	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
Q	0005737	cellular_component	cytoplasm
Q	0006364	biological_process	rRNA processing
Q	0006397	biological_process	mRNA processing
Q	0008033	biological_process	tRNA processing
Q	0008266	molecular_function	poly(U) RNA binding
Q	0008380	biological_process	RNA splicing
Q	0030490	biological_process	maturation of SSU-rRNA
Q	0030620	molecular_function	U2 snRNA binding
Q	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
Q	0120114	cellular_component	Sm-like protein family complex
Q	0120115	cellular_component	Lsm2-8 complex
Q	1905323	biological_process	telomerase holoenzyme complex assembly
Q	1990726	cellular_component	Lsm1-7-Pat1 complex
Q	1990904	cellular_component	ribonucleoprotein complex
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0000956	biological_process	nuclear-transcribed mRNA catabolic process
R	0003723	molecular_function	RNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005681	cellular_component	spliceosomal complex
R	0005682	cellular_component	U5 snRNP
R	0005686	cellular_component	U2 snRNP
R	0005688	cellular_component	U6 snRNP
R	0005697	cellular_component	telomerase holoenzyme complex
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006364	biological_process	rRNA processing
R	0006397	biological_process	mRNA processing
R	0008033	biological_process	tRNA processing
R	0008266	molecular_function	poly(U) RNA binding
R	0008380	biological_process	RNA splicing
R	0030620	molecular_function	U2 snRNA binding
R	0045292	biological_process	mRNA cis splicing, via spliceosome
R	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
R	0071004	cellular_component	U2-type prespliceosome
R	0071013	cellular_component	catalytic step 2 spliceosome
R	0097526	cellular_component	spliceosomal tri-snRNP complex
R	0120114	cellular_component	Sm-like protein family complex
R	0120115	cellular_component	Lsm2-8 complex
R	1905323	biological_process	telomerase holoenzyme complex assembly
R	1990726	cellular_component	Lsm1-7-Pat1 complex
R	1990904	cellular_component	ribonucleoprotein complex
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005681	cellular_component	spliceosomal complex
S	0005682	cellular_component	U5 snRNP
S	0005686	cellular_component	U2 snRNP
S	0005688	cellular_component	U6 snRNP
S	0005697	cellular_component	telomerase holoenzyme complex
S	0005730	cellular_component	nucleolus
S	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
S	0006364	biological_process	rRNA processing
S	0006397	biological_process	mRNA processing
S	0008033	biological_process	tRNA processing
S	0008266	molecular_function	poly(U) RNA binding
S	0008380	biological_process	RNA splicing
S	0022613	biological_process	ribonucleoprotein complex biogenesis
S	0030620	molecular_function	U2 snRNA binding
S	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
S	0120115	cellular_component	Lsm2-8 complex
S	1905323	biological_process	telomerase holoenzyme complex assembly
S	1990726	cellular_component	Lsm1-7-Pat1 complex
S	1990904	cellular_component	ribonucleoprotein complex
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0000932	cellular_component	P-body
T	0003723	molecular_function	RNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005681	cellular_component	spliceosomal complex
T	0005682	cellular_component	U5 snRNP
T	0005686	cellular_component	U2 snRNP
T	0005688	cellular_component	U6 snRNP
T	0005697	cellular_component	telomerase holoenzyme complex
T	0005730	cellular_component	nucleolus
T	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
T	0005737	cellular_component	cytoplasm
T	0006364	biological_process	rRNA processing
T	0006397	biological_process	mRNA processing
T	0008033	biological_process	tRNA processing
T	0008266	molecular_function	poly(U) RNA binding
T	0008380	biological_process	RNA splicing
T	0030490	biological_process	maturation of SSU-rRNA
T	0030620	molecular_function	U2 snRNA binding
T	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
T	0120114	cellular_component	Sm-like protein family complex
T	0120115	cellular_component	Lsm2-8 complex
T	1905323	biological_process	telomerase holoenzyme complex assembly
T	1990726	cellular_component	Lsm1-7-Pat1 complex
T	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN C 114

Chain	Residue
C	ASP62

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 81

Chain	Residue
A	GLU49
A	GLU58
A	HIS60
B	TYR69

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 76

Chain	Residue
B	HOH82
B	GLU43
B	ASP59
B	HOH80
B	HOH81

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 77

Chain	Residue
B	SER32
B	CYS33
B	HOH78

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN F 114

Chain	Residue
F	ASP63

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN F 115

Chain	Residue
B	CYS33
F	ASP27

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 81

Chain	Residue
D	GLU49
D	GLU58
D	HIS60
E	ARG20
E	TYR69

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN D 82

Chain	Residue
D	GLU9

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN O 114

Chain	Residue
O	ASP62

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P 81

Chain	Residue
P	GLU49
P	GLU58
P	HIS60
Q	TYR69

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN P 82

Chain	Residue
P	ASP12

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN Q 76

Chain	Residue
Q	GLU43
Q	ASP59
Q	HOH78
Q	HOH79
Q	HOH82

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN Q 77

Chain	Residue
Q	SER32
Q	CYS33
Q	HOH81
Q	HOH85

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN R 114

Chain	Residue
R	ASP63

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN R 115

Chain	Residue
Q	CYS33
R	ASP27

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN S 81

Chain	Residue
S	GLU49
S	GLU58
S	HIS60
T	ARG20
T	TYR69

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	146
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)