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3SVG

Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand

Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 1
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 2
ChainResidue
AGLU163
AHOH238
ATYR137
AILE138
AGLN159
ALYS160

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE EDO A 3
ChainResidue
AVAL69
ATYR137
AASN140
ALYS141
APRO142
AVAL147
ALYS160
AHOH239
AHOH253

site_idAC4
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ODR A 169
ChainResidue
AHOH7
AHOH18
AHOH23
ATRP81
APRO82
AGLN85
AASP96
ALYS99
AASN140
AILE146
AMET149

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

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PDB entries from 2024-11-06

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