3SUG

Crystal structure of NS3/4A protease variant A156T in complex with MK-5172

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0019087	biological_process	transformation of host cell by virus

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SUE A 1201

Chain	Residue
A	GLN1041
A	SER1138
A	ALA1139
A	PHE1154
A	ARG1155
A	THR1156
A	ALA1157
A	ASP1168
A	SO41202
A	PHE1043
A	TYR1056
A	HIS1057
A	GLY1058
A	ILE1132
A	LEU1135
A	LYS1136
A	GLY1137

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1202

Chain	Residue
A	TYR1006
A	GLN1008
A	TYR1056
A	SUE1201
A	HOH1306
A	HOH1318
A	HOH1322

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1203

Chain	Residue
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

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