3SUD
Crystal structure of NS3/4A protease in complex with MK-5172
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0019087 | biological_process | symbiont-mediated transformation of host cell |
| B | 0006508 | biological_process | proteolysis |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0019087 | biological_process | symbiont-mediated transformation of host cell |
| C | 0006508 | biological_process | proteolysis |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0019087 | biological_process | symbiont-mediated transformation of host cell |
| D | 0006508 | biological_process | proteolysis |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0019087 | biological_process | symbiont-mediated transformation of host cell |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SUE A 1201 |
| Chain | Residue |
| A | PHE1043 |
| A | GLY1137 |
| A | SER1138 |
| A | ALA1139 |
| A | PHE1154 |
| A | ARG1155 |
| A | ALA1156 |
| A | ALA1157 |
| A | TYR1056 |
| A | HIS1057 |
| A | GLY1058 |
| A | VAL1078 |
| A | ASP1081 |
| A | ARG1123 |
| A | LEU1135 |
| A | LYS1136 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1202 |
| Chain | Residue |
| A | LYS1068 |
| D | THR1178 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1203 |
| Chain | Residue |
| A | CYS1097 |
| A | CYS1099 |
| A | CYS1145 |
| A | HIS1149 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SUE B 1201 |
| Chain | Residue |
| B | GLN1041 |
| B | PHE1043 |
| B | TYR1056 |
| B | HIS1057 |
| B | GLY1058 |
| B | VAL1078 |
| B | ASP1081 |
| B | ILE1132 |
| B | LYS1136 |
| B | GLY1137 |
| B | SER1138 |
| B | ALA1139 |
| B | PHE1154 |
| B | ARG1155 |
| B | ALA1156 |
| B | ALA1157 |
| B | HOH1306 |
| B | HOH1307 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 1202 |
| Chain | Residue |
| B | CYS1097 |
| B | CYS1099 |
| B | CYS1145 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SUE C 1201 |
| Chain | Residue |
| C | GLN1041 |
| C | PHE1043 |
| C | TYR1056 |
| C | HIS1057 |
| C | VAL1078 |
| C | ASP1081 |
| C | ARG1123 |
| C | ILE1132 |
| C | LEU1135 |
| C | LYS1136 |
| C | GLY1137 |
| C | SER1138 |
| C | ALA1139 |
| C | PHE1154 |
| C | ARG1155 |
| C | ALA1156 |
| C | ALA1157 |
| C | HOH1319 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN C 1202 |
| Chain | Residue |
| C | CYS1097 |
| C | CYS1099 |
| C | CYS1145 |
| site_id | AC8 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SUE D 1201 |
| Chain | Residue |
| D | GLN1041 |
| D | PHE1043 |
| D | TYR1056 |
| D | HIS1057 |
| D | GLY1058 |
| D | VAL1078 |
| D | ASP1081 |
| D | ILE1132 |
| D | LEU1135 |
| D | LYS1136 |
| D | GLY1137 |
| D | SER1138 |
| D | ALA1139 |
| D | PHE1154 |
| D | ARG1155 |
| D | ALA1156 |
| D | ALA1157 |
| D | SER1159 |
| D | HOH1320 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1202 |
| Chain | Residue |
| D | CYS1097 |
| D | CYS1099 |
| D | CYS1145 |
| D | HIS1149 |
