3STK
Crystal Structure of human LFABP complex with two molecules of palmitic acid (holo-LFABP)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003682 | molecular_function | chromatin binding |
| A | 0005324 | molecular_function | long-chain fatty acid transmembrane transporter activity |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005782 | cellular_component | peroxisomal matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0008289 | molecular_function | lipid binding |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0015909 | biological_process | long-chain fatty acid transport |
| A | 0016209 | molecular_function | antioxidant activity |
| A | 0032000 | biological_process | positive regulation of fatty acid beta-oxidation |
| A | 0032052 | molecular_function | bile acid binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0033552 | biological_process | response to vitamin B3 |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0043154 | biological_process | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| A | 0045179 | cellular_component | apical cortex |
| A | 0050892 | biological_process | intestinal absorption |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070301 | biological_process | cellular response to hydrogen peroxide |
| A | 0070538 | molecular_function | oleic acid binding |
| A | 0071456 | biological_process | cellular response to hypoxia |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 1901363 | molecular_function | heterocyclic compound binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PLM A 130 |
| Chain | Residue |
| A | SER39 |
| A | ILE52 |
| A | GLU72 |
| A | THR102 |
| A | ASN111 |
| A | ARG122 |
| A | PLM131 |
| A | HOH227 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PLM A 131 |
| Chain | Residue |
| A | SER56 |
| A | ASN111 |
| A | ARG122 |
| A | PLM130 |
| A | ALA54 |
Functional Information from PROSITE/UniProt
| site_id | PS00214 |
| Number of Residues | 18 |
| Details | FABP Cytosolic fatty-acid binding proteins signature. GKYqLqsQeNFEaFMKAI |
| Chain | Residue | Details |
| A | GLY5-ILE22 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER11 | |
| A | SER56 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P12710 |
| Chain | Residue | Details |
| A | LYS31 | |
| A | LYS36 | |
| A | LYS46 | |
| A | LYS57 | |
| A | LYS78 | |
| A | LYS90 | |
| A | LYS121 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02692 |
| Chain | Residue | Details |
| A | SER39 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR51 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P12710 |
| Chain | Residue | Details |
| A | SER100 |
