3SSN
MycE Methyltransferase from the Mycinamycin Biosynthetic Pathway in Complex with Mg, SAH, and Mycinamycin VI
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| A | 0032259 | biological_process | methylation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0102302 | molecular_function | mycinamicin VI 2''-O-methyltransferase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008171 | molecular_function | O-methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0017000 | biological_process | antibiotic biosynthetic process |
| B | 0032259 | biological_process | methylation |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0102302 | molecular_function | mycinamicin VI 2''-O-methyltransferase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0008171 | molecular_function | O-methyltransferase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0017000 | biological_process | antibiotic biosynthetic process |
| C | 0032259 | biological_process | methylation |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051289 | biological_process | protein homotetramerization |
| C | 0102302 | molecular_function | mycinamicin VI 2''-O-methyltransferase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0008171 | molecular_function | O-methyltransferase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0017000 | biological_process | antibiotic biosynthetic process |
| D | 0032259 | biological_process | methylation |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051289 | biological_process | protein homotetramerization |
| D | 0102302 | molecular_function | mycinamicin VI 2''-O-methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 501 |
| Chain | Residue |
| A | ASP275 |
| A | HIS278 |
| A | ASP304 |
| A | HOH510 |
| A | HOH520 |
| A | MVI701 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAH A 601 |
| Chain | Residue |
| A | GLU202 |
| A | GLY204 |
| A | GLY206 |
| A | TYR208 |
| A | SER217 |
| A | ASP234 |
| A | ILE235 |
| A | GLY251 |
| A | ASP252 |
| A | GLN253 |
| A | ASP275 |
| A | GLY276 |
| A | SER277 |
| A | HIS282 |
| A | HOH415 |
| A | HOH506 |
| D | PHE387 |
| A | THR173 |
| A | PRO174 |
| A | LYS175 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE MVI A 701 |
| Chain | Residue |
| A | PHE172 |
| A | PRO174 |
| A | HIS180 |
| A | TYR208 |
| A | ASP275 |
| A | HIS278 |
| A | ASP304 |
| A | TRP306 |
| A | HOH454 |
| A | MG501 |
| A | HOH510 |
| A | HOH520 |
| C | GLY140 |
| C | GLN147 |
| D | ILE383 |
| D | LEU390 |
| D | ALA393 |
| D | SER394 |
| D | HOH419 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 400 |
| Chain | Residue |
| A | ARG188 |
| D | ARG188 |
| D | HIS189 |
| D | TYR363 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 401 |
| Chain | Residue |
| A | ARG49 |
| A | ALA155 |
| A | SER159 |
| A | ARG160 |
| A | SER223 |
| A | HOH486 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 501 |
| Chain | Residue |
| C | ASP275 |
| C | GLU303 |
| C | ASP304 |
| C | HOH525 |
| C | HOH528 |
| C | MVI701 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH C 601 |
| Chain | Residue |
| B | PHE387 |
| C | THR173 |
| C | PRO174 |
| C | LYS175 |
| C | GLU202 |
| C | GLY204 |
| C | GLY206 |
| C | TYR208 |
| C | SER217 |
| C | ASP234 |
| C | ILE235 |
| C | GLY251 |
| C | ASP252 |
| C | GLN253 |
| C | ASP275 |
| C | GLY276 |
| C | SER277 |
| C | HIS282 |
| C | HOH510 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE MVI C 701 |
| Chain | Residue |
| A | GLY140 |
| A | GLN147 |
| B | ILE383 |
| B | LEU390 |
| B | ALA393 |
| B | SER394 |
| C | PHE172 |
| C | PRO174 |
| C | HIS180 |
| C | ASP275 |
| C | HIS278 |
| C | ASP304 |
| C | TRP306 |
| C | HOH447 |
| C | HOH495 |
| C | MG501 |
| C | HOH525 |
| C | HOH528 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS C 400 |
| Chain | Residue |
| C | ALA155 |
| C | SER159 |
| C | ARG160 |
| C | SER223 |
| C | HOH448 |
| C | ARG49 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG D 501 |
| Chain | Residue |
| D | ASP275 |
| D | ASP304 |
| site_id | BC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SAH D 601 |
| Chain | Residue |
| D | THR173 |
| D | LYS175 |
| D | GLU202 |
| D | GLY204 |
| D | VAL205 |
| D | GLY206 |
| D | TYR208 |
| D | SER217 |
| D | ASP234 |
| D | ILE235 |
| D | GLY251 |
| D | ASP252 |
| D | GLN253 |
| D | ASP275 |
| D | GLY276 |
| D | SER277 |
| D | HIS282 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 400 |
| Chain | Residue |
| A | ARG77 |
| A | ARG85 |
| A | VAL87 |
| D | ARG77 |
| D | ARG85 |
| D | GLU91 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"21884704","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 45 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21884704","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
