Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL I 501 |
| Chain | Residue |
| A | GLY109 |
| A | TYR110 |
| A | ASN111 |
| I | ASN60 |
| I | ASP61 |
| I | LYS62 |
| I | HOH644 |
| I | HOH650 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 502 |
| Chain | Residue |
| B | TYR110 |
| B | ASN111 |
| B | HOH852 |
| B | HOH885 |
| J | ASN60 |
| B | GLY109 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 503 |
| Chain | Residue |
| A | TYR66 |
| B | SER218 |
| B | LYS219 |
| B | TYR251 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 999 |
| Chain | Residue |
| A | HIS142 |
| A | HIS146 |
| A | GLU166 |
| C | ASN56 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 998 |
| Chain | Residue |
| A | ASP57 |
| A | ASP59 |
| A | GLN61 |
| A | HOH599 |
| A | HOH600 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 997 |
| Chain | Residue |
| A | ASP138 |
| A | GLU177 |
| A | ASP185 |
| A | GLU187 |
| A | GLU190 |
| A | HOH656 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 996 |
| Chain | Residue |
| A | TYR193 |
| A | THR194 |
| A | ILE197 |
| A | ASP200 |
| A | HOH659 |
| A | HOH695 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 995 |
| Chain | Residue |
| A | GLU177 |
| A | ASN183 |
| A | ASP185 |
| A | GLU190 |
| A | HOH525 |
| A | HOH533 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 999 |
| Chain | Residue |
| B | HIS142 |
| B | HIS146 |
| B | GLU166 |
| D | ASN56 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 998 |
| Chain | Residue |
| B | ASP57 |
| B | ASP59 |
| B | GLN61 |
| B | HOH722 |
| B | HOH725 |
| B | HOH969 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 997 |
| Chain | Residue |
| B | ASP138 |
| B | GLU177 |
| B | ASP185 |
| B | GLU187 |
| B | GLU190 |
| B | HOH799 |
| B | NA995 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 996 |
| Chain | Residue |
| B | TYR193 |
| B | THR194 |
| B | ILE197 |
| B | ASP200 |
| B | HOH883 |
| B | HOH884 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA B 995 |
| Chain | Residue |
| B | GLU177 |
| B | ASN183 |
| B | ASP185 |
| B | GLU190 |
| B | HOH795 |
| B | HOH797 |
| B | CA997 |
Functional Information from PROSITE/UniProt
| site_id | PS01186 |
| Number of Residues | 15 |
| Details | EGF_2 EGF-like domain signature 2. CyCedGYardvngk.C |
| Chain | Residue | Details |
| I | CYS63-CYS77 | |
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV |
| Chain | Residue | Details |
| A | VAL139-VAL148 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Cleavage => ECO:0000305 |
| Chain | Residue | Details |
| I | SER88 | |
| J | SER88 | |
| Chain | Residue | Details |
| A | HIS231 | |
| B | HIS231 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | HIS142 | |
| A | HIS146 | |
| A | GLU166 | |
| A | GLU177 | |
| A | ASN183 | |
| A | ASP185 | |
| A | GLU187 | |
| A | GLU190 | |
| A | TYR193 | |
| A | THR194 | |
| A | ILE197 | |
| A | ASP200 | |
| B | ASP57 | |
| B | ASP59 | |
| B | GLN61 | |
| B | ASP138 | |
| B | HIS142 | |
| B | HIS146 | |
| B | GLU166 | |
| B | GLU177 | |
| B | ASN183 | |
| B | ASP185 | |
| B | GLU187 | |
| B | GLU190 | |
| B | TYR193 | |
| B | THR194 | |
| B | ILE197 | |
| B | ASP200 | |
| A | ASP57 | |
| A | ASP59 | |
| A | GLN61 | |
| A | ASP138 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 176 |
| Chain | Residue | Details |
| A | HIS142 | metal ligand |
| A | GLU143 | electrostatic stabiliser, metal ligand |
| A | HIS146 | metal ligand |
| A | TYR157 | electrostatic stabiliser, hydrogen bond donor, steric role |
| A | GLU166 | metal ligand |
| A | ASP226 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | HIS231 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 176 |
| Chain | Residue | Details |
| B | HIS142 | metal ligand |
| B | GLU143 | electrostatic stabiliser, metal ligand |
| B | HIS146 | metal ligand |
| B | TYR157 | electrostatic stabiliser, hydrogen bond donor, steric role |
| B | GLU166 | metal ligand |
| B | ASP226 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| B | HIS231 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
