Functional Information from GO Data
Chain | GOid | namespace | contents |
X | 0004146 | molecular_function | dihydrofolate reductase activity |
X | 0005829 | cellular_component | cytosol |
X | 0006730 | biological_process | one-carbon metabolic process |
X | 0016491 | molecular_function | oxidoreductase activity |
X | 0046452 | biological_process | dihydrofolate metabolic process |
X | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
X | 0046655 | biological_process | folic acid metabolic process |
X | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE Q27 X 168 |
Chain | Residue |
X | LEU6 |
X | PHE93 |
X | NAP169 |
X | VAL7 |
X | ALA8 |
X | LEU21 |
X | ASP28 |
X | LEU29 |
X | VAL32 |
X | THR47 |
X | ILE51 |
site_id | AC2 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE NAP X 169 |
Chain | Residue |
X | VAL7 |
X | ALA8 |
X | ILE15 |
X | GLY16 |
X | PHE17 |
X | ASN19 |
X | GLN20 |
X | LEU21 |
X | GLY44 |
X | ARG45 |
X | LYS46 |
X | THR47 |
X | LEU63 |
X | THR64 |
X | SER65 |
X | HIS78 |
X | ILE80 |
X | PHE93 |
X | GLY95 |
X | GLN96 |
X | THR97 |
X | LEU98 |
X | GLU101 |
X | THR122 |
X | Q27168 |
X | HOH194 |
X | HOH231 |
X | HOH237 |
X | HOH276 |
X | HOH277 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlkhVkklS |
Chain | Residue | Details |
X | VAL14-SER36 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
X | LEU6 | |
X | ASP28 | |
X | SER50 | |
X | ARG58 | |
X | PHE93 | |
Chain | Residue | Details |
X | VAL7 | |
X | ILE15 | |
X | GLY44 | |
X | LEU63 | |
X | GLU101 | |
X | THR122 | |