Functional Information from GO Data
| Chain | GOid | namespace | contents |
| X | 0004146 | molecular_function | dihydrofolate reductase activity |
| X | 0005829 | cellular_component | cytosol |
| X | 0006730 | biological_process | one-carbon metabolic process |
| X | 0016491 | molecular_function | oxidoreductase activity |
| X | 0044281 | biological_process | small molecule metabolic process |
| X | 0046452 | biological_process | dihydrofolate metabolic process |
| X | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| X | 0046655 | biological_process | folic acid metabolic process |
| X | 0050661 | molecular_function | NADP binding |
| X | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE M23 X 168 |
| Chain | Residue |
| X | LEU6 |
| X | NAP169 |
| X | VAL7 |
| X | ALA8 |
| X | LEU21 |
| X | ASP28 |
| X | LEU29 |
| X | VAL32 |
| X | SER50 |
| X | PHE93 |
| site_id | AC2 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NAP X 169 |
| Chain | Residue |
| X | VAL7 |
| X | ALA8 |
| X | ILE15 |
| X | GLY16 |
| X | PHE17 |
| X | ASN19 |
| X | GLN20 |
| X | LEU21 |
| X | GLY44 |
| X | ARG45 |
| X | LYS46 |
| X | THR47 |
| X | LEU63 |
| X | THR64 |
| X | SER65 |
| X | ILE80 |
| X | PHE93 |
| X | GLY95 |
| X | GLN96 |
| X | THR97 |
| X | LEU98 |
| X | GLU101 |
| X | THR122 |
| X | M23168 |
| X | HOH189 |
| X | HOH204 |
| X | HOH220 |
| X | HOH226 |
| X | HOH264 |
| X | HOH274 |
| X | HOH277 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlkhVkklS |
| Chain | Residue | Details |
| X | VAL14-SER36 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 155 |
| Details | Domain: {"description":"DHFR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00660","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19280600","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19280600","evidenceCode":"ECO:0000269"}]} |
