Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 40 |
| Details | BINDING SITE FOR CHAIN C OF R1 PEPTIDE |
| Chain | Residue |
| A | ASP134 |
| A | GLY222 |
| A | ASN223 |
| A | MET224 |
| A | ILE225 |
| A | ASP227 |
| A | ASN228 |
| A | SER232 |
| A | TYR234 |
| A | LYS235 |
| A | TYR236 |
| A | VAL137 |
| A | TYR251 |
| A | ALA254 |
| A | MET273 |
| B | GLY139 |
| C | HOH33 |
| C | HOH181 |
| C | HOH184 |
| C | HOH219 |
| C | HOH248 |
| C | HOH277 |
| A | THR140 |
| C | HOH300 |
| C | HOH365 |
| C | HOH438 |
| C | HOH440 |
| C | HOH666 |
| D | LEU6 |
| D | PRO7 |
| D | LEU8 |
| D | PHE9 |
| D | SER10 |
| A | GLN141 |
| F | VAL1 |
| A | TYR142 |
| A | ALA170 |
| A | TYR175 |
| A | PHE183 |
| A | PHE201 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR CHAIN D OF R1 PEPTIDE |
| Chain | Residue |
| A | THR171 |
| A | PRO184 |
| A | PRO185 |
| A | THR186 |
| A | GLU187 |
| A | MET190 |
| A | ASN228 |
| A | LYS230 |
| C | PHE9 |
| C | SER10 |
| C | LYS11 |
| C | PHE12 |
| C | GLY13 |
| C | SER14 |
| C | HIS17 |
| D | HOH287 |
| F | VAL1 |
| F | PHE2 |
| site_id | AC3 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR CHAIN E OF R1 PEPTIDE |
| Chain | Residue |
| A | ASN173 |
| A | GLN174 |
| B | ASP134 |
| B | GLN141 |
| B | TYR142 |
| B | ALA170 |
| B | TYR175 |
| B | LEU176 |
| B | GLY222 |
| B | ASN223 |
| B | MET224 |
| B | ILE225 |
| B | PRO226 |
| B | ASP227 |
| B | ASN228 |
| B | SER232 |
| B | TYR234 |
| B | LYS235 |
| B | TYR236 |
| B | TYR251 |
| B | ALA254 |
| B | TYR262 |
| B | MET273 |
| B | HOH626 |
| E | HOH86 |
| E | HOH192 |
| E | HOH364 |
| F | LEU6 |
| F | PRO7 |
| F | LEU8 |
| F | PHE9 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR CHAIN F OF R1 PEPTIDE |
| Chain | Residue |
| D | GLU4 |
| E | PHE9 |
| E | SER10 |
| E | LYS11 |
| E | PHE12 |
| E | GLY13 |
| E | SER14 |
| F | HOH341 |
| A | THR171 |
| A | GLY172 |
| A | ASN173 |
| B | PRO184 |
| B | PRO185 |
| B | THR186 |
| B | GLU187 |
| B | ASN228 |
| B | LYS230 |
| C | SER10 |
