3SQG
Crystal structure of a methyl-coenzyme M reductase purified from Black Sea mats
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015948 | biological_process | methanogenesis |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| B | 0015948 | biological_process | methanogenesis |
| B | 0016740 | molecular_function | transferase activity |
| B | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| C | 0015948 | biological_process | methanogenesis |
| C | 0016740 | molecular_function | transferase activity |
| C | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| D | 0015948 | biological_process | methanogenesis |
| D | 0016740 | molecular_function | transferase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| E | 0015948 | biological_process | methanogenesis |
| E | 0016740 | molecular_function | transferase activity |
| E | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| F | 0015948 | biological_process | methanogenesis |
| F | 0016740 | molecular_function | transferase activity |
| F | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| G | 0015948 | biological_process | methanogenesis |
| G | 0016740 | molecular_function | transferase activity |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| H | 0015948 | biological_process | methanogenesis |
| H | 0016740 | molecular_function | transferase activity |
| H | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| I | 0015948 | biological_process | methanogenesis |
| I | 0016740 | molecular_function | transferase activity |
| I | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE TP7 A 1002 |
| Chain | Residue |
| A | LYS284 |
| A | HOH652 |
| A | HOH748 |
| A | HOH908 |
| B | PHE358 |
| B | TYR363 |
| B | GLY364 |
| B | GLY365 |
| B | HIS375 |
| B | VAL377 |
| B | HOH452 |
| A | PHE334 |
| D | ARG239 |
| D | LYS270 |
| D | MHS271 |
| A | MET338 |
| A | PHE344 |
| A | PHE462 |
| A | MHO499 |
| A | ASN500 |
| A | VAL501 |
| A | HOH597 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE COM A 1003 |
| Chain | Residue |
| A | TYR347 |
| A | PHE462 |
| A | PHE463 |
| B | PHE357 |
| B | TYR363 |
| C | LEU117 |
| C | ARG120 |
| D | M431001 |
| site_id | AC3 |
| Number of Residues | 40 |
| Details | BINDING SITE FOR RESIDUE M43 A 1001 |
| Chain | Residue |
| A | ALA152 |
| A | VAL153 |
| A | ILE154 |
| A | GLN155 |
| A | MET158 |
| A | GLN244 |
| A | MET247 |
| A | ALA257 |
| A | HOH638 |
| A | HOH647 |
| A | HOH650 |
| A | HOH660 |
| A | HOH670 |
| A | HOH698 |
| A | HOH782 |
| D | GLY340 |
| D | VAL342 |
| D | GLY343 |
| D | PHE344 |
| D | THR345 |
| D | GLN346 |
| D | TYR347 |
| D | PHE415 |
| D | GLY416 |
| D | GLY461 |
| D | PHE462 |
| D | COM1003 |
| E | SER361 |
| E | ILE362 |
| E | TYR363 |
| F | LEU117 |
| F | SER118 |
| F | GLY119 |
| F | ARG153 |
| F | THR154 |
| F | VAL155 |
| F | HIS156 |
| F | GLY157 |
| F | HIS158 |
| F | HOH380 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE TP7 A 580 |
| Chain | Residue |
| A | ARG239 |
| A | LYS270 |
| A | MHS271 |
| A | HOH612 |
| A | HOH615 |
| A | HOH668 |
| A | HOH680 |
| A | HOH716 |
| D | LYS284 |
| D | PHE334 |
| D | MET338 |
| D | PHE344 |
| D | PHE462 |
| D | MHO499 |
| D | ASN500 |
| E | TYR363 |
| E | GLY364 |
| E | GLY365 |
| E | HIS375 |
| E | VAL377 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 1PE A 581 |
| Chain | Residue |
| C | ARG161 |
| D | VAL58 |
| D | ASN59 |
| A | ASP16 |
| A | PHE18 |
| A | ALA19 |
| A | GLU20 |
| A | THR27 |
| A | TYR32 |
| A | TYR76 |
| A | ARG186 |
| A | PGE582 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGE A 582 |
| Chain | Residue |
| A | THR31 |
| A | TYR32 |
| A | 1PE581 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE A 583 |
| Chain | Residue |
| A | LYS38 |
| A | PRO79 |
| A | MET88 |
| A | ASN90 |
| A | ASN553 |
| D | VAL58 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 584 |
| Chain | Residue |
| A | GLU20 |
| A | LYS21 |
| A | SER24 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 585 |
| Chain | Residue |
| A | LYS130 |
| A | GLU131 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 586 |
| Chain | Residue |
| A | HIS121 |
| A | TYR140 |
| A | TYR253 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 587 |
| Chain | Residue |
| A | ALA229 |
| A | ARG230 |
| A | THR232 |
| D | ALA229 |
| D | ARG230 |
| D | THR232 |
| site_id | BC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE P6G B 434 |
| Chain | Residue |
| B | GLY166 |
| B | LYS171 |
| B | MET172 |
| B | LEU173 |
| B | VAL174 |
| B | ASP175 |
| B | ASN189 |
| B | PRO191 |
| B | HIS194 |
| B | TYR372 |
| B | THR407 |
| B | TYR411 |
| B | HOH952 |
| B | HOH1577 |
| B | HOH1691 |
| D | TYR267 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 435 |
| Chain | Residue |
| B | ALA48 |
| B | LYS107 |
| B | ARG108 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 436 |
| Chain | Residue |
| B | ARG62 |
| B | HOH1902 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL C 281 |
| Chain | Residue |
| C | TYR109 |
| C | LYS110 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 282 |
| Chain | Residue |
| C | ARG128 |
| C | LYS197 |
| C | HOH1497 |
| site_id | BC8 |
| Number of Residues | 39 |
| Details | BINDING SITE FOR RESIDUE M43 D 1001 |
| Chain | Residue |
| A | GLY340 |
| A | GLY341 |
| A | VAL342 |
| A | GLY343 |
| A | PHE344 |
| A | THR345 |
| A | GLN346 |
| A | TYR347 |
| A | PHE415 |
| A | GLY416 |
| A | GLY461 |
| A | PHE462 |
| A | HOH661 |
| A | COM1003 |
| B | SER361 |
| B | ILE362 |
| B | TYR363 |
| C | LEU117 |
| C | SER118 |
| C | GLY119 |
| C | ARG153 |
| C | THR154 |
| C | VAL155 |
| C | HIS156 |
| C | GLY157 |
| C | HIS158 |
| C | HOH293 |
| D | ALA152 |
| D | VAL153 |
| D | ILE154 |
| D | GLN155 |
| D | GLN244 |
| D | MET247 |
| D | ALA257 |
| D | HOH593 |
| D | HOH615 |
| D | HOH635 |
| D | HOH641 |
| D | HOH688 |
| site_id | BC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE COM D 1003 |
| Chain | Residue |
| A | M431001 |
| D | TYR347 |
| D | PHE462 |
| D | PHE463 |
| E | PHE357 |
| E | SER361 |
| E | TYR363 |
| F | LEU117 |
| F | ARG120 |
| site_id | CC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 1PE D 580 |
| Chain | Residue |
| D | ASP16 |
| D | PHE18 |
| D | ALA19 |
| D | GLU20 |
| D | TYR76 |
| F | ARG161 |
| G | VAL58 |
| G | ASN59 |
| G | ARG186 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE D 581 |
| Chain | Residue |
| D | LYS38 |
| D | PRO79 |
| D | MET88 |
| D | ASN90 |
| D | ASN553 |
| D | HOH1035 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE D 582 |
| Chain | Residue |
| D | PRO134 |
| D | ASP177 |
| D | LEU180 |
| D | LYS216 |
| D | ILE218 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 583 |
| Chain | Residue |
| D | LYS130 |
| D | GLU131 |
| D | HOH1501 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 584 |
| Chain | Residue |
| B | GLY68 |
| B | HOH1017 |
| D | LYS380 |
| D | ASN518 |
| site_id | CC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 1PE E 434 |
| Chain | Residue |
| A | TYR267 |
| E | MET172 |
| E | ASP175 |
| E | PRO191 |
| E | HIS194 |
| E | VAL370 |
| E | TYR372 |
| E | THR407 |
| E | TYR411 |
| E | HOH1309 |
| E | HOH1664 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL E 435 |
| Chain | Residue |
| B | ILE118 |
| B | SER120 |
| E | ILE118 |
| site_id | CC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE 1PE F 281 |
| Chain | Residue |
| F | ARG43 |
| F | GLY46 |
| F | GLU47 |
| site_id | CC9 |
| Number of Residues | 39 |
| Details | BINDING SITE FOR RESIDUE M43 G 1001 |
| Chain | Residue |
| G | ALA152 |
| G | VAL153 |
| G | ILE154 |
| G | GLN155 |
| G | GLN244 |
| G | MET247 |
| G | ALA257 |
| G | GLY340 |
| G | VAL342 |
| G | GLY343 |
| G | PHE344 |
| G | THR345 |
| G | GLN346 |
| G | TYR347 |
| G | PHE415 |
| G | GLY416 |
| G | GLY461 |
| G | PHE462 |
| G | HOH599 |
| G | HOH618 |
| G | HOH625 |
| G | HOH626 |
| G | HOH692 |
| G | HOH702 |
| G | HOH706 |
| G | HOH929 |
| G | COM1003 |
| H | SER361 |
| H | ILE362 |
| H | TYR363 |
| I | LEU117 |
| I | SER118 |
| I | GLY119 |
| I | ARG153 |
| I | THR154 |
| I | VAL155 |
| I | HIS156 |
| I | GLY157 |
| I | HIS158 |
| site_id | DC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE TP7 G 1002 |
| Chain | Residue |
| G | ARG239 |
| G | LYS270 |
| G | MHS271 |
| G | LYS284 |
| G | PHE334 |
| G | MET338 |
| G | PHE462 |
| G | MHO499 |
| G | ASN500 |
| G | VAL501 |
| G | HOH585 |
| G | HOH608 |
| G | HOH1225 |
| G | HOH1251 |
| G | HOH1985 |
| H | TYR363 |
| H | GLY364 |
| H | GLY365 |
| H | HIS375 |
| H | VAL377 |
| H | HOH902 |
| site_id | DC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE COM G 1003 |
| Chain | Residue |
| G | TYR347 |
| G | PHE462 |
| G | PHE463 |
| G | M431001 |
| H | PHE357 |
| H | SER361 |
| H | TYR363 |
| H | HOH1344 |
| I | LEU117 |
| I | ARG120 |
| site_id | DC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 1PE G 580 |
| Chain | Residue |
| A | VAL58 |
| A | ASN59 |
| D | ARG186 |
| G | ASP16 |
| G | PHE18 |
| G | ALA19 |
| G | GLU20 |
| G | THR27 |
| I | ARG161 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE G 581 |
| Chain | Residue |
| G | LYS38 |
| G | MET88 |
| G | ASN90 |
| G | ASN553 |
| G | HOH1266 |
| G | HOH1357 |
| site_id | DC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGE G 582 |
| Chain | Residue |
| G | THR31 |
| G | TYR32 |
| G | HOH1736 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA G 583 |
| Chain | Residue |
| G | ALA229 |
| G | ALA229 |
| G | ARG230 |
| G | ARG230 |
| G | THR232 |
| G | THR232 |
| site_id | DC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 1PE H 434 |
| Chain | Residue |
| G | TYR267 |
| G | HOH751 |
| H | LYS171 |
| H | MET172 |
| H | LEU173 |
| H | VAL174 |
| H | ASP175 |
| H | ASN189 |
| H | PRO191 |
| H | HIS194 |
| H | TYR372 |
| H | TYR411 |
| H | HOH1900 |
| site_id | DC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 H 435 |
| Chain | Residue |
| H | ARG62 |
| site_id | DC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 I 281 |
| Chain | Residue |
| I | ARG276 |
| I | HOH1117 |
