3SQ7

Crystal Structure Analysis of the Yeast Tyrosyl-DNA Phosphodiesterase H432N_Glu Mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0006281	biological_process	DNA repair
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0005634	cellular_component	nucleus
B	0006281	biological_process	DNA repair
B	0008081	molecular_function	phosphoric diester hydrolase activity
C	0005634	cellular_component	nucleus
C	0006281	biological_process	DNA repair
C	0008081	molecular_function	phosphoric diester hydrolase activity
D	0005634	cellular_component	nucleus
D	0006281	biological_process	DNA repair
D	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 2

Chain	Residue
A	SER318
A	ARG319
A	ALA320
A	ARG321

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 4

Chain	Residue
A	ASN494
A	THR495
A	HOH585
B	THR423
B	ARG424

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 6

Chain	Residue
A	THR423
A	ARG424
A	ARG425

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 7

Chain	Residue
A	SER475
A	ARG476
A	LYS477
A	HOH752

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 5

Chain	Residue
B	SER318
B	ARG319
B	ALA320
B	ARG321

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 1

Chain	Residue
D	SER318
D	ARG319
D	ALA320
D	ARG321

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 3

Chain	Residue
C	ASN494
C	THR495
D	THR423
D	ARG424
D	ARG425

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:16751265

Chain	Residue	Details
A	HIS182
B	HIS182
C	HIS182
D	HIS182

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:17707402

Chain	Residue	Details
A	ASN432
B	ASN432
C	ASN432
D	ASN432

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9NUW8

Chain	Residue	Details
A	LYS184
A	LYS434
B	LYS184
B	LYS434
C	LYS184
C	LYS434
D	LYS184
D	LYS434

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Interaction with DNA => ECO:0000250|UniProtKB:Q9NUW8

Chain	Residue	Details
A	SER467
B	SER467
C	SER467
D	SER467

---