3SPD

Crystal structure of aprataxin ortholog Hnt3 in complex with DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
B	0003824	molecular_function	catalytic activity
C	0003824	molecular_function	catalytic activity
D	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 601

Chain	Residue
A	CYS200
A	CYS203
A	HIS217
A	GLU221

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 701

Chain	Residue
D	HOH498
A	ARG202
A	TRP225
A	LYS228
A	HOH485
D	HIS83

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 702

Chain	Residue
A	HIS85
A	GLY140
A	ARG187
A	GLY188
A	HOH272
B	LYS199

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 703

Chain	Residue
A	HIS93
A	SER95
A	LEU96
A	HOH267
A	HOH1000

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 704

Chain	Residue
A	SER121
A	GLN122
A	GLN123
A	HOH245
A	HOH265
A	HOH771
A	HOH1034
A	HOH1072

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 601

Chain	Residue
B	CYS200
B	CYS203
B	HIS217
B	GLU221

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 701

Chain	Residue
A	HIS83
A	HOH764
B	ARG202
B	TRP225
B	LYS228

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 702

Chain	Residue
B	HIS85
B	GLY140
B	ARG187
B	GLY188
B	HOH257
C	LYS199

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 703

Chain	Residue
B	HIS93
B	SER95
B	LEU96
B	HOH270
B	HOH272

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 704

Chain	Residue
B	HOH1
B	SER121
B	GLN122
B	GLN123
B	HOH271
B	HOH811
C	HOH290

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 601

Chain	Residue
C	CYS200
C	CYS203
C	HIS217
C	GLU221

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 701

Chain	Residue
B	HIS83
C	ARG202
C	TRP225
C	LYS228

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 702

Chain	Residue
C	HIS85
C	GLY140
C	ARG187
C	HOH1010
D	LYS199

---

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 703

Chain	Residue
C	LEU81
C	HIS93
C	SER95
C	LEU96
C	HOH256
C	HOH261
C	HOH1091
C	HOH1092

---

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 704

Chain	Residue
B	HOH262
C	SER121
C	GLN122
C	GLN123
C	HOH341
C	HOH961
C	HOH1044

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 601

Chain	Residue
D	CYS200
D	CYS203
D	HIS217
D	GLU221

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 701

Chain	Residue
C	HIS83
D	ARG202
D	TRP225
D	LYS228
D	HOH360
D	HOH829

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 702

Chain	Residue
A	LYS199
D	HIS85
D	GLY140
D	ARG187
D	HOH266

---

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 703

Chain	Residue
D	LEU81
D	HIS93
D	SER95
D	LEU96
D	HOH246
D	HOH292

---

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 704

Chain	Residue
D	SER121
D	GLN122
D	GLN123
D	HOH272
D	HOH291
D	HOH809
D	HOH1018

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	488
Details	Domain: {"description":"HIT"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	88
Details	Region: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"21984208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984210","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26007660","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21984210","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26007660","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21984210","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26007660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SPD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XBA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"21984210","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26007660","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---