3SL0
Crystal Structure of P. falciparum arginase complexed with 2-amino-6-borono-2-(difluoromethyl)hexanoic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000050 | biological_process | urea cycle |
| A | 0004053 | molecular_function | arginase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006525 | biological_process | arginine metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019547 | biological_process | arginine catabolic process to ornithine |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 412 |
| Chain | Residue |
| A | ASP216 |
| A | HIS218 |
| A | ASP323 |
| A | ASP325 |
| A | MN413 |
| A | FB5414 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN A 413 |
| Chain | Residue |
| A | ASP323 |
| A | MN412 |
| A | FB5414 |
| A | HOH598 |
| A | HIS193 |
| A | ASP216 |
| A | ASP220 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE FB5 A 414 |
| Chain | Residue |
| A | ASP216 |
| A | HIS218 |
| A | ASP220 |
| A | ASN222 |
| A | SER229 |
| A | HIS233 |
| A | GLY234 |
| A | ASP274 |
| A | ASP323 |
| A | ASP325 |
| A | GLU368 |
| A | HIS381 |
| A | MN412 |
| A | MN413 |
| A | HOH436 |
| A | HOH479 |
| A | HOH508 |
| A | HOH511 |
| A | HOH598 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20527960, ECO:0000269|PubMed:21728378, ECO:0007744|PDB:3MMR, ECO:0007744|PDB:3SL0, ECO:0007744|PDB:3SL1 |
| Chain | Residue | Details |
| A | HIS193 | |
| A | ASP216 | |
| A | HIS218 | |
| A | ASP220 | |
| A | ASP323 | |
| A | ASP325 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:20527960, ECO:0000305|PubMed:21728378, ECO:0007744|PDB:3MMR, ECO:0007744|PDB:3SL0, ECO:0007744|PDB:3SL1 |
| Chain | Residue | Details |
| A | ASN222 | |
| A | SER229 | |
| A | ASP274 |
