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3SIZ

Crystal structure of the mutant S127A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004590molecular_functionorotidine-5'-phosphate decarboxylase activity
A0005829cellular_componentcytosol
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006221biological_processpyrimidine nucleotide biosynthetic process
A0016831molecular_functioncarboxy-lyase activity
A0044205biological_process'de novo' UMP biosynthetic process
B0004590molecular_functionorotidine-5'-phosphate decarboxylase activity
B0005829cellular_componentcytosol
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006221biological_processpyrimidine nucleotide biosynthetic process
B0016831molecular_functioncarboxy-lyase activity
B0044205biological_process'de novo' UMP biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE BMP A 229
ChainResidue
AASP20
AARG203
AHOH237
AHOH245
AHOH248
AHOH250
AHOH261
AHOH269
AHOH287
BASP75
BILE76
ALYS42
BTHR79
AASP70
ALYS72
AMET126
AALA127
APRO180
AGLN185
AGLY202

site_idAC2
Number of Residues20
DetailsBINDING SITE FOR RESIDUE BMP B 229
ChainResidue
AASP75
AILE76
ATHR79
BASP20
BLYS42
BASP70
BLYS72
BMET126
BALA127
BPRO180
BGLN185
BGLY202
BARG203
BHOH237
BHOH243
BHOH244
BHOH247
BHOH263
BHOH271
BHOH316

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL B 230
ChainResidue
AASN210
AHOH321
AHOH404
BSER158
BTHR159
BPRO161
BGLY186
BGLY187
BHOH248
BHOH288

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL B 231
ChainResidue
BALA103
BASP104
BARG107
BLEU149
BHOH278

Functional Information from PROSITE/UniProt
site_idPS00156
Number of Residues14
DetailsOMPDECASE Orotidine 5'-phosphate decarboxylase active site. IIaDfKvaDIPeTN
ChainResidueDetails
AILE67-ASN80

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor
ChainResidueDetails
ALYS72
BLYS72

site_idSWS_FT_FI2
Number of Residues14
DetailsBINDING:
ChainResidueDetails
BLYS42
BASP70
BALA127
BPRO180
BGLY202
BARG203
AASP20
ALYS42
AASP70
AALA127
APRO180
AGLY202
AARG203
BASP20

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PDB entries from 2024-05-15

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