3SGV
Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1290
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0008834 | molecular_function | ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0016094 | biological_process | polyprenol biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0036094 | molecular_function | small molecule binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043164 | biological_process | Gram-negative-bacterium-type cell wall biogenesis |
| A | 0045547 | molecular_function | ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051301 | biological_process | cell division |
| A | 0071555 | biological_process | cell wall organization |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008360 | biological_process | regulation of cell shape |
| B | 0008834 | molecular_function | ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity |
| B | 0009252 | biological_process | peptidoglycan biosynthetic process |
| B | 0016094 | biological_process | polyprenol biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0036094 | molecular_function | small molecule binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043164 | biological_process | Gram-negative-bacterium-type cell wall biogenesis |
| B | 0045547 | molecular_function | ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051301 | biological_process | cell division |
| B | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 2BJ A 2001 |
| Chain | Residue |
| A | ILE24 |
| A | ALA69 |
| A | PHE70 |
| A | SER71 |
| A | GLU73 |
| A | ASN74 |
| A | ARG194 |
| A | HOH286 |
| A | HOH342 |
| A | 2BJ3001 |
| A | 2BJ4001 |
| A | MET25 |
| A | ASP26 |
| A | GLY27 |
| A | ASN28 |
| A | GLY29 |
| A | ARG39 |
| A | HIS43 |
| A | TYR68 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 2BJ A 3001 |
| Chain | Residue |
| A | MET25 |
| A | LEU67 |
| A | ALA69 |
| A | PHE70 |
| A | TRP75 |
| A | MET86 |
| A | PHE89 |
| A | GLU96 |
| A | PHE116 |
| A | ILE141 |
| A | ALA142 |
| A | ALA143 |
| A | ASN144 |
| A | HOH266 |
| A | HOH274 |
| A | HOH368 |
| A | 2BJ2001 |
| A | 2BJ4001 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE 2BJ A 4001 |
| Chain | Residue |
| A | HIS43 |
| A | TRP75 |
| A | 2BJ2001 |
| A | 2BJ3001 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 2BJ B 5001 |
| Chain | Residue |
| A | GLN163 |
| B | HIS43 |
| B | LYS44 |
| B | ALA47 |
| B | LYS48 |
| B | VAL50 |
| B | ARG51 |
| B | LEU88 |
| B | ALA92 |
| B | GLU96 |
| B | GLN168 |
| B | HOH268 |
| B | HOH371 |
| B | 2BJ1001 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 2BJ B 1001 |
| Chain | Residue |
| B | MET25 |
| B | ASP26 |
| B | GLY27 |
| B | ASN28 |
| B | GLY29 |
| B | HIS43 |
| B | VAL50 |
| B | ALA69 |
| B | LEU85 |
| B | PHE89 |
| B | HOH284 |
| B | HOH340 |
| B | 2BJ5001 |
Functional Information from PROSITE/UniProt
| site_id | PS01066 |
| Number of Residues | 18 |
| Details | UPP_SYNTHASE Undecaprenyl pyrophosphate synthase family signature. DLVIRTGGehRiSnFLLW |
| Chain | Residue | Details |
| B | ASP190-TRP207 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15044730","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15044730","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Required for continued chain elongation"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for determining product length"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
