3SGI

Crystal structure of DNA ligase A BRCT domain deleted mutant of Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003911	molecular_function	DNA ligase (NAD+) activity
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AMP A 616

Chain	Residue
A	GLN18
A	LYS324
A	HOH620
A	LEU92
A	LEU122
A	LYS123
A	ILE124
A	ARG144
A	GLU184
A	HIS236
A	VAL298

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Functional Information from PROSITE/UniProt

site_id	PS01055
Number of Residues	30
Details	DNA_LIGASE_N1 NAD-dependent DNA ligase signature 1. KIDGVAlslvYreGrLtrasTRGDGrtGED

Chain	Residue	Details
A	LYS123-ASP152

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site_id	PS01056
Number of Residues	16
Details	DNA_LIGASE_N2 NAD-dependent DNA ligase signature 2. VGRTGrITpFafMtPV

Chain	Residue	Details
A	VAL341-VAL356

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"N6-AMP-lysine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01588","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01588","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01588","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15901723","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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