3SGI

Crystal structure of DNA ligase A BRCT domain deleted mutant of Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003911	molecular_function	DNA ligase (NAD+) activity
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AMP A 616

Chain	Residue
A	GLN18
A	LYS324
A	HOH620
A	LEU92
A	LEU122
A	LYS123
A	ILE124
A	ARG144
A	GLU184
A	HIS236
A	VAL298

---

Functional Information from PROSITE/UniProt

site_id	PS01055
Number of Residues	30
Details	DNA_LIGASE_N1 NAD-dependent DNA ligase signature 1. KIDGVAlslvYreGrLtrasTRGDGrtGED

Chain	Residue	Details
A	LYS123-ASP152

---

site_id	PS01056
Number of Residues	16
Details	DNA_LIGASE_N2 NAD-dependent DNA ligase signature 2. VGRTGrITpFafMtPV

Chain	Residue	Details
A	VAL341-VAL356

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: N6-AMP-lysine intermediate => ECO:0000255|HAMAP-Rule:MF_01588

Chain	Residue	Details
A	LYS123

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01588

Chain	Residue	Details
A	ASP41
A	GLU121
A	LYS324
A	CYS418
A	CYS421
A	CYS437
A	CYS443

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01588, ECO:0000305|PubMed:15901723

Chain	Residue	Details
A	SER91
A	ARG144
A	GLU184
A	LYS300

---