3SEP
E. coli (lacZ) beta-galactosidase (S796A)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0004565 | molecular_function | beta-galactosidase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0005990 | biological_process | lactose catabolic process |
| A | 0009341 | cellular_component | beta-galactosidase complex |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0030246 | molecular_function | carbohydrate binding |
| A | 0031420 | molecular_function | alkali metal ion binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0004565 | molecular_function | beta-galactosidase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0005990 | biological_process | lactose catabolic process |
| B | 0009341 | cellular_component | beta-galactosidase complex |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0030246 | molecular_function | carbohydrate binding |
| B | 0031420 | molecular_function | alkali metal ion binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| C | 0004565 | molecular_function | beta-galactosidase activity |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0005990 | biological_process | lactose catabolic process |
| C | 0009341 | cellular_component | beta-galactosidase complex |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| C | 0030246 | molecular_function | carbohydrate binding |
| C | 0031420 | molecular_function | alkali metal ion binding |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| D | 0004565 | molecular_function | beta-galactosidase activity |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0005990 | biological_process | lactose catabolic process |
| D | 0009341 | cellular_component | beta-galactosidase complex |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| D | 0030246 | molecular_function | carbohydrate binding |
| D | 0031420 | molecular_function | alkali metal ion binding |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 3001 |
| Chain | Residue |
| A | GLU416 |
| A | HIS418 |
| A | GLU461 |
| A | HOH4152 |
| A | HOH4796 |
| A | HOH4846 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 3002 |
| Chain | Residue |
| A | GLN163 |
| A | ASP193 |
| A | ASP15 |
| A | ASN18 |
| A | VAL21 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 3101 |
| Chain | Residue |
| A | ASP201 |
| A | PHE601 |
| A | ASN604 |
| A | HOH4266 |
| A | HOH4696 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 3102 |
| Chain | Residue |
| A | PHE556 |
| A | TYR559 |
| A | PRO560 |
| A | LEU562 |
| A | HOH4374 |
| A | HOH4527 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 3103 |
| Chain | Residue |
| A | PHE931 |
| A | PRO932 |
| A | LEU967 |
| A | THR970 |
| A | HOH4199 |
| A | HOH4475 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS A 8001 |
| Chain | Residue |
| A | THR229 |
| A | VAL330 |
| A | GLY331 |
| A | ARG448 |
| A | ASN449 |
| A | PRO451 |
| A | ARG482 |
| A | HOH4011 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 8002 |
| Chain | Residue |
| A | ARG557 |
| A | HIS622 |
| A | GLN625 |
| A | GLN628 |
| A | GLN718 |
| A | HOH4198 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 8003 |
| Chain | Residue |
| A | LYS380 |
| A | ASN383 |
| A | PHE626 |
| A | TYR642 |
| A | TRP708 |
| A | HOH4206 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS A 8004 |
| Chain | Residue |
| A | PRO32 |
| A | PHE33 |
| A | ALA34 |
| A | TRP36 |
| A | ASP45 |
| A | ALA327 |
| A | HOH4397 |
| A | DMS8016 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 8005 |
| Chain | Residue |
| A | THR271 |
| A | LEU291 |
| A | ARG292 |
| A | HOH4568 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 8006 |
| Chain | Residue |
| A | ARG505 |
| A | GLU508 |
| A | PRO1001 |
| A | VAL1003 |
| A | HOH4036 |
| A | HOH4355 |
| A | HOH4791 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 8007 |
| Chain | Residue |
| A | LEU54 |
| A | ASN55 |
| A | LEU125 |
| A | HOH4583 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 8008 |
| Chain | Residue |
| A | PRO480 |
| A | HOH4201 |
| A | HOH4204 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 8009 |
| Chain | Residue |
| A | PRO106 |
| A | PRO115 |
| A | DMS8012 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 8010 |
| Chain | Residue |
| A | ILE576 |
| A | PRO584 |
| A | TRP585 |
| A | SER586 |
| A | ARG973 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 8011 |
| Chain | Residue |
| A | VAL289 |
| A | THR290 |
| A | ARG292 |
| A | HOH4508 |
| A | HOH4568 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 8012 |
| Chain | Residue |
| A | TYR105 |
| A | ILE107 |
| A | THR108 |
| A | PRO596 |
| A | HOH4429 |
| A | DMS8009 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 8013 |
| Chain | Residue |
| A | LYS621 |
| A | ILE714 |
| A | TRP717 |
| A | HOH4661 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS A 8015 |
| Chain | Residue |
| A | HIS93 |
| A | GLY94 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 8016 |
| Chain | Residue |
| A | TRP36 |
| A | ASP45 |
| A | ARG46 |
| A | PRO47 |
| A | DMS8004 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 8017 |
| Chain | Residue |
| A | GLU57 |
| A | LEU125 |
| A | THR126 |
| A | HOH4467 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 8018 |
| Chain | Residue |
| A | GLN266 |
| A | VAL267 |
| A | ALA268 |
| A | SER269 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 8019 |
| Chain | Residue |
| A | ARG230 |
| A | PHE231 |
| A | ASN232 |
| A | VAL239 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE DMS A 8020 |
| Chain | Residue |
| A | TRP518 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 8021 |
| Chain | Residue |
| A | SER132 |
| A | TRP133 |
| A | HIS216 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 8022 |
| Chain | Residue |
| A | GLU314 |
| A | HIS316 |
| A | GLY320 |
| A | LEU322 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 3001 |
| Chain | Residue |
| B | GLU416 |
| B | HIS418 |
| B | GLU461 |
| B | HOH4030 |
| B | HOH4967 |
| B | HOH5038 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 3002 |
| Chain | Residue |
| B | ASP15 |
| B | ASN18 |
| B | VAL21 |
| B | GLN163 |
| B | ASP193 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 3007 |
| Chain | Residue |
| B | HOH4718 |
| B | HOH4976 |
| B | HOH5039 |
| B | HOH5123 |
| C | HOH4815 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 3101 |
| Chain | Residue |
| B | ASP201 |
| B | PHE601 |
| B | ASN604 |
| B | HOH4280 |
| B | HOH4820 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 3102 |
| Chain | Residue |
| B | PHE556 |
| B | TYR559 |
| B | PRO560 |
| B | LEU562 |
| B | HOH4395 |
| B | HOH4968 |
| site_id | DC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 3103 |
| Chain | Residue |
| B | PHE931 |
| B | PRO932 |
| B | LEU967 |
| B | THR970 |
| B | HOH4216 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 3104 |
| Chain | Residue |
| B | SER647 |
| B | ASP648 |
| B | ASN649 |
| B | GLU650 |
| B | LEU670 |
| B | HOH4870 |
| site_id | DC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS B 8001 |
| Chain | Residue |
| B | THR229 |
| B | VAL330 |
| B | GLY331 |
| B | ARG448 |
| B | ASN449 |
| B | PRO451 |
| B | ARG482 |
| B | HOH4027 |
| site_id | DC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 8002 |
| Chain | Residue |
| B | ARG557 |
| B | HIS622 |
| B | GLN625 |
| B | GLN628 |
| B | HOH4214 |
| site_id | DC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS B 8003 |
| Chain | Residue |
| B | LYS380 |
| B | ASN383 |
| B | PHE626 |
| B | TYR642 |
| B | TRP708 |
| B | HOH4223 |
| site_id | EC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS B 8004 |
| Chain | Residue |
| B | PRO32 |
| B | PHE33 |
| B | TRP36 |
| B | ASP45 |
| B | ALA327 |
| B | HOH4405 |
| B | HOH4417 |
| B | HOH4577 |
| site_id | EC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 8005 |
| Chain | Residue |
| B | THR271 |
| B | LEU291 |
| B | ARG292 |
| B | HOH4613 |
| B | HOH4689 |
| site_id | EC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 8006 |
| Chain | Residue |
| B | THR257 |
| B | GLU314 |
| B | HIS316 |
| B | GLY320 |
| B | HOH4010 |
| site_id | EC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS B 8007 |
| Chain | Residue |
| B | LEU54 |
| B | ASN55 |
| B | LEU125 |
| B | HOH5005 |
| site_id | EC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 8008 |
| Chain | Residue |
| B | VAL335 |
| B | PRO480 |
| B | HOH4218 |
| B | HOH4221 |
| B | HOH4487 |
| site_id | EC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS B 8009 |
| Chain | Residue |
| B | PRO106 |
| B | HOH4363 |
| B | DMS8021 |
| site_id | EC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS B 8010 |
| Chain | Residue |
| B | PRO584 |
| B | TRP585 |
| B | SER586 |
| B | ARG973 |
| B | HOH4117 |
| C | ASN581 |
| site_id | EC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 8011 |
| Chain | Residue |
| B | GLY275 |
| B | VAL289 |
| B | THR290 |
| B | ARG292 |
| B | HOH4715 |
| site_id | EC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS B 8012 |
| Chain | Residue |
| B | GLY593 |
| B | THR595 |
| site_id | FC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS B 8013 |
| Chain | Residue |
| B | ASP428 |
| B | PRO430 |
| C | GLN445 |
| C | TRP474 |
| C | VAL478 |
| C | HOH4018 |
| site_id | FC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS B 8014 |
| Chain | Residue |
| B | HIS93 |
| B | GLY94 |
| B | TYR95 |
| B | HOH4568 |
| site_id | FC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS B 8015 |
| Chain | Residue |
| B | TRP36 |
| B | ARG46 |
| B | PRO47 |
| B | HOH4476 |
| B | HOH4491 |
| B | HOH4792 |
| site_id | FC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS B 8016 |
| Chain | Residue |
| B | GLU57 |
| B | LEU125 |
| B | THR126 |
| B | HOH4495 |
| site_id | FC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 8017 |
| Chain | Residue |
| B | LEU377 |
| B | THR706 |
| B | ALA707 |
| B | GLU710 |
| B | HOH4785 |
| site_id | FC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 8018 |
| Chain | Residue |
| B | THR44 |
| B | ASP45 |
| B | HOH4476 |
| B | HOH4791 |
| C | DMS8007 |
| site_id | FC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 8019 |
| Chain | Residue |
| B | PHE989 |
| B | ARG1013 |
| B | TYR1014 |
| B | HIS1015 |
| B | HOH5032 |
| site_id | FC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS B 8020 |
| Chain | Residue |
| B | PHE629 |
| B | ARG630 |
| B | LEU631 |
| B | TRP720 |
| site_id | FC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS B 8021 |
| Chain | Residue |
| B | TYR105 |
| B | PRO106 |
| B | THR108 |
| B | PRO596 |
| B | HOH4893 |
| B | DMS8009 |
| site_id | GC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS B 8022 |
| Chain | Residue |
| B | PRO306 |
| B | ASN307 |
| site_id | GC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 8023 |
| Chain | Residue |
| B | ARG37 |
| B | SER132 |
| B | TRP133 |
| B | GLU136 |
| B | HIS216 |
| site_id | GC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 3001 |
| Chain | Residue |
| C | GLU416 |
| C | HIS418 |
| C | GLU461 |
| C | HOH4044 |
| C | HOH4959 |
| C | HOH5027 |
| site_id | GC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 3002 |
| Chain | Residue |
| C | ASP15 |
| C | ASN18 |
| C | VAL21 |
| C | GLN163 |
| C | ASP193 |
| site_id | GC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA C 3101 |
| Chain | Residue |
| C | ASP201 |
| C | PHE601 |
| C | ASN604 |
| C | HOH4300 |
| C | HOH4846 |
| site_id | GC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA C 3102 |
| Chain | Residue |
| C | PHE556 |
| C | TYR559 |
| C | PRO560 |
| C | LEU562 |
| C | HOH4418 |
| site_id | GC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA C 3103 |
| Chain | Residue |
| C | PHE931 |
| C | PRO932 |
| C | LEU967 |
| C | THR970 |
| C | HOH4231 |
| C | HOH4681 |
| site_id | GC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA C 3104 |
| Chain | Residue |
| C | SER647 |
| C | GLU650 |
| C | LEU670 |
| C | HOH4694 |
| C | HOH4865 |
| site_id | GC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DMS C 8001 |
| Chain | Residue |
| C | THR229 |
| C | VAL330 |
| C | GLY331 |
| C | ARG333 |
| C | ASN449 |
| C | HIS450 |
| C | PRO451 |
| C | ARG482 |
| C | HOH4041 |
| site_id | HC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS C 8002 |
| Chain | Residue |
| C | ARG557 |
| C | HIS622 |
| C | GLN625 |
| C | GLN628 |
| site_id | HC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS C 8003 |
| Chain | Residue |
| C | ASN383 |
| C | PHE626 |
| C | TYR642 |
| C | TRP708 |
| C | HOH4238 |
| site_id | HC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS C 8004 |
| Chain | Residue |
| C | PHE33 |
| C | ALA34 |
| C | TRP36 |
| C | ASP45 |
| C | ALA327 |
| C | HOH4430 |
| C | HOH4613 |
| C | DMS8016 |
| site_id | HC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS C 8005 |
| Chain | Residue |
| C | GLY270 |
| C | THR271 |
| C | ARG292 |
| C | LEU293 |
| site_id | HC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS C 8006 |
| Chain | Residue |
| C | GLU314 |
| C | HIS316 |
| C | GLY320 |
| C | LEU322 |
| site_id | HC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS C 8007 |
| Chain | Residue |
| B | HOH4850 |
| B | DMS8018 |
| C | SER53 |
| C | LEU54 |
| C | ASN55 |
| C | LEU125 |
| C | PHE127 |
| site_id | HC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS C 8008 |
| Chain | Residue |
| C | GLU334 |
| C | VAL335 |
| C | ARG336 |
| C | PRO480 |
| C | HOH4236 |
| C | HOH4928 |
| site_id | HC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS C 8009 |
| Chain | Residue |
| C | PRO106 |
| C | HOH4387 |
| site_id | HC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS C 8010 |
| Chain | Residue |
| C | ILE576 |
| C | PRO584 |
| C | TRP585 |
| C | SER586 |
| C | ARG973 |
| site_id | IC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS C 8011 |
| Chain | Residue |
| C | GLY275 |
| C | GLU277 |
| C | VAL289 |
| C | THR290 |
| C | ARG292 |
| C | HOH4649 |
| C | HOH4655 |
| C | HOH4914 |
| site_id | IC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS C 8012 |
| Chain | Residue |
| C | VAL84 |
| C | VAL85 |
| C | HIS93 |
| site_id | IC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS C 8013 |
| Chain | Residue |
| C | LYS621 |
| C | ILE714 |
| C | TRP717 |
| C | HOH4359 |
| site_id | IC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS C 8014 |
| Chain | Residue |
| B | GLN445 |
| B | TRP474 |
| B | VAL478 |
| B | HOH4873 |
| C | ASP428 |
| C | PRO430 |
| C | HOH4977 |
| site_id | IC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS C 8015 |
| Chain | Residue |
| C | HIS93 |
| C | GLY94 |
| C | TYR95 |
| C | HOH4985 |
| C | HOH5062 |
| site_id | IC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS C 8016 |
| Chain | Residue |
| C | ASP45 |
| C | DMS8004 |
| site_id | IC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS C 8017 |
| Chain | Residue |
| C | PHE629 |
| C | GLN718 |
| C | TRP720 |
| C | HOH4262 |
| site_id | IC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS C 8018 |
| Chain | Residue |
| C | GLU57 |
| C | LEU125 |
| C | THR126 |
| C | HOH4525 |
| site_id | IC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS C 8019 |
| Chain | Residue |
| C | ARG230 |
| C | PHE231 |
| C | ARG237 |
| site_id | JC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS C 8020 |
| Chain | Residue |
| C | ARG37 |
| C | TRP133 |
| C | HIS216 |
| site_id | JC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS D 8014 |
| Chain | Residue |
| A | ASP428 |
| A | HOH4716 |
| D | GLN445 |
| D | TRP474 |
| D | VAL478 |
| site_id | JC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 3001 |
| Chain | Residue |
| D | GLU416 |
| D | HIS418 |
| D | GLU461 |
| D | HOH4040 |
| D | HOH4180 |
| D | HOH4904 |
| site_id | JC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 3002 |
| Chain | Residue |
| D | ASP15 |
| D | ASN18 |
| D | VAL21 |
| D | GLN163 |
| D | ASP193 |
| site_id | JC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA D 3101 |
| Chain | Residue |
| D | ASP201 |
| D | PHE601 |
| D | ASN604 |
| D | HOH4292 |
| D | HOH4765 |
| site_id | JC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA D 3102 |
| Chain | Residue |
| D | PHE556 |
| D | TYR559 |
| D | PRO560 |
| D | LEU562 |
| D | HOH4400 |
| site_id | JC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA D 3103 |
| Chain | Residue |
| D | PHE931 |
| D | PRO932 |
| D | LEU967 |
| D | THR970 |
| D | HOH4226 |
| D | HOH4717 |
| site_id | JC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DMS D 8001 |
| Chain | Residue |
| D | THR229 |
| D | VAL330 |
| D | GLY331 |
| D | ARG333 |
| D | ASN449 |
| D | HIS450 |
| D | PRO451 |
| D | ARG482 |
| D | HOH4037 |
| site_id | JC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS D 8002 |
| Chain | Residue |
| D | ARG557 |
| D | HIS622 |
| D | GLN623 |
| D | GLN628 |
| D | GLN718 |
| D | HOH4044 |
| site_id | KC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS D 8003 |
| Chain | Residue |
| D | LYS380 |
| D | ASN383 |
| D | PHE384 |
| D | PHE626 |
| D | TYR642 |
| D | TRP708 |
| D | HOH4103 |
| D | HOH4233 |
| site_id | KC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DMS D 8004 |
| Chain | Residue |
| D | PRO32 |
| D | PHE33 |
| D | ALA34 |
| D | TRP36 |
| D | ASP45 |
| D | ARG310 |
| D | ALA327 |
| D | HOH4567 |
| D | DMS8013 |
| site_id | KC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS D 8005 |
| Chain | Residue |
| D | GLY270 |
| D | THR271 |
| D | ARG292 |
| D | HOH4595 |
| D | HOH4690 |
| site_id | KC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS D 8006 |
| Chain | Residue |
| D | ARG505 |
| D | GLU508 |
| D | PRO1001 |
| D | VAL1003 |
| D | GLN1008 |
| D | HOH4063 |
| D | HOH4379 |
| site_id | KC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS D 8007 |
| Chain | Residue |
| D | SER53 |
| D | LEU54 |
| D | ASN55 |
| site_id | KC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS D 8008 |
| Chain | Residue |
| D | GLU334 |
| D | VAL335 |
| D | PRO480 |
| D | SER481 |
| D | HOH4231 |
| site_id | KC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS D 8009 |
| Chain | Residue |
| D | ILE576 |
| D | PRO584 |
| D | TRP585 |
| D | SER586 |
| D | ARG973 |
| site_id | KC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS D 8010 |
| Chain | Residue |
| D | GLY275 |
| D | GLY276 |
| D | VAL289 |
| D | THR290 |
| D | HOH4591 |
| D | HOH4736 |
| site_id | KC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS D 8011 |
| Chain | Residue |
| D | VAL84 |
| D | VAL85 |
| D | HIS93 |
| site_id | LC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS D 8012 |
| Chain | Residue |
| D | LYS621 |
| D | ARG699 |
| D | ILE714 |
| D | TRP717 |
| D | HOH4340 |
| site_id | LC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS D 8013 |
| Chain | Residue |
| D | TRP36 |
| D | ASP45 |
| D | HOH4486 |
| D | HOH4633 |
| D | HOH4702 |
| D | DMS8004 |
Functional Information from PROSITE/UniProt
| site_id | PS00608 |
| Number of Residues | 15 |
| Details | GLYCOSYL_HYDROL_F2_2 Glycosyl hydrolases family 2 acid/base catalyst. DRNHPSVIIWSlg.NE |
| Chain | Residue | Details |
| A | ASP447-GLU461 |
| site_id | PS00719 |
| Number of Residues | 26 |
| Details | GLYCOSYL_HYDROL_F2_1 Glycosyl hydrolases family 2 signature 1. NaVRCSHYPnhplWYtlcDryGLYVV |
| Chain | Residue | Details |
| A | ASN385-VAL410 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"6420154","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"1350782","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11045615","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Site: {"description":"Transition state stabilizer"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for ensuring that an appropriate proportion of lactose is converted to allolactose"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 10 |
| Details | M-CSA 422 |
| Chain | Residue | Details |
| A | ASP201 | |
| A | ASN604 | |
| A | HIS357 | |
| A | HIS391 | |
| A | GLU416 | |
| A | HIS418 | |
| A | GLU461 | |
| A | GLU537 | |
| A | ASN597 | |
| A | PHE601 |
| site_id | MCSA2 |
| Number of Residues | 10 |
| Details | M-CSA 422 |
| Chain | Residue | Details |
| B | ASP201 | |
| B | ASN604 | |
| B | HIS357 | |
| B | HIS391 | |
| B | GLU416 | |
| B | HIS418 | |
| B | GLU461 | |
| B | GLU537 | |
| B | ASN597 | |
| B | PHE601 |
| site_id | MCSA3 |
| Number of Residues | 10 |
| Details | M-CSA 422 |
| Chain | Residue | Details |
| C | ASP201 | |
| C | ASN604 | |
| C | HIS357 | |
| C | HIS391 | |
| C | GLU416 | |
| C | HIS418 | |
| C | GLU461 | |
| C | GLU537 | |
| C | ASN597 | |
| C | PHE601 |
| site_id | MCSA4 |
| Number of Residues | 10 |
| Details | M-CSA 422 |
| Chain | Residue | Details |
| D | ASP201 | |
| D | ASN604 | |
| D | HIS357 | |
| D | HIS391 | |
| D | GLU416 | |
| D | HIS418 | |
| D | GLU461 | |
| D | GLU537 | |
| D | ASN597 | |
| D | PHE601 |
