3SDB
Crystal structure of C176A mutant of glutamine-dependent NAD+ synthetase from M. tuberculosis in apo form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003952 | molecular_function | NAD+ synthase (glutamine-hydrolyzing) activity |
| A | 0004359 | molecular_function | glutaminase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008795 | molecular_function | NAD+ synthase activity |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0009435 | biological_process | NAD+ biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0042802 | molecular_function | identical protein binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 264 |
| Details | Domain: {"description":"CN hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00054","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor; for glutaminase activity","evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15748981","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19270703","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For glutaminase activity","evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15748981","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19270703","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; for glutaminase activity","evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15748981","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19270703","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3SYT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"3DLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SYT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SZG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3SEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SYT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SZG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3DLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SZG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3SEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SYT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SZG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3SEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SYT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_02090","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3DLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SYT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SZG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PDB","id":"3DLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SZG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
